
Methyl 4-Methylcyclohexanecarboxylate synthesis
- Product Name:Methyl 4-Methylcyclohexanecarboxylate
- CAS Number:51181-40-9
- Molecular formula:C9H16O2
- Molecular Weight:156.22

67-56-1
776 suppliers
$9.00/25ml

4331-54-8
117 suppliers
$10.00/250mg

51181-40-9
20 suppliers
inquiry
Yield:51181-40-9 83%
Reaction Conditions:
with thionyl chloride in neat (no solvent) at 0 - 25; for 16 h;Inert atmosphere;Temperature;
Steps:
8 Synthesis of Methyl 4-methylcyclohexane-1-carboxylate (1):
To a solution of 4-methylcyclohexane-1-carboxylic acid (SM-1) (5 g, 35.1 mmol) in methanol (25 mL) was added thionyl chloride (5.1 mL, 70.3 mmol) at 0 °C under nitrogen atmosphere and then stirred for 16 h at room temperature. After consumption of the starting material (by TLC), volatiles were evaporated under reduced pressure. Crude mixture was diluted with EtOAc (20 mL) and washed with water (20 mL), saturated NaHCO3 solution (20 mL) and brine solution (20 mL). Separated organic layer was dried over Na2SO4 and concentrated to obtain compound 1 (4.5 g, 83%) as colorless liquid. (0383) 1H NMR: (400MHz, DMSO-d6): δ 3.57 (s, 3H), 2.24-2.18 (tt, J = 3.6, 12.2 Hz, 1H), 1.89-1.81 (m, 2H), 1.72-1.64 (m, 2H), 1.38-1.24 (m, 3H), 0.98-0.88 (m, 2H), 0.85 (d, J = 6.5 Hz, 3H). LCMS (m/z): 157.12 [M++1]
References:
WO2018/26763,2018,A1 Location in patent:Page/Page column 59

120-61-6
472 suppliers
$6.00/25g

94-60-0
236 suppliers
$6.00/10g

105-08-8
376 suppliers
$5.00/25g

51181-40-9
20 suppliers
inquiry

34885-03-5
49 suppliers
$110.00/1g

32529-79-6
83 suppliers
$6.00/250mg

13380-85-3
61 suppliers
$42.00/250mg

51181-40-9
20 suppliers
inquiry

98955-27-2
49 suppliers
$40.00/100mg

6493-79-4
11 suppliers
$544.00/500mg

99-75-2
284 suppliers
$6.00/10g

51181-40-9
20 suppliers
inquiry

4331-54-8
117 suppliers
$10.00/250mg

51181-40-9
20 suppliers
inquiry