ChemicalBook CAS DataBase List MOXONIDINE IMPURITY A

MOXONIDINE IMPURITY A synthesis

9synthesis methods

Product Name:MOXONIDINE IMPURITY A
CAS Number:352457-35-3
Molecular formula:C8H9Cl2N5
Molecular Weight:246.1

5-Pyrimidinamine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-, ethanedioate (1:1)

287099-40-5
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352457-35-3
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75439-01-9
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75438-57-2
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$40.00/50mg

Yield:75438-57-2 94%

Reaction Conditions:

with sodium hydroxide in water at 20; pH=10 - 11; for 1 h;Product distribution / selectivity;

Steps:

23

20% aqueous NaOH solution was added at ambient temperature to a suspension of mono-Moxonidine oxalate (3.6 g) in water (18 ml) to produce a pH of 10-11. The mixture was stirred for one hour and the precipitate was collected by filtration, washed with water and 2-propanol and dried at 50° C overnight to yield 2.48 g of Moxonidine base in 94.0% yield, [containing 0.04% of impurity II and 1.25% of impurity III]. A mixture of 2.48 g of Moxonidine base and 12.5 ml of DMSO was heated at 90° C to obtain a clear solution. The solution was cooled to room temperature and kept at this temperature for about 3 hours. A colorless precipitate was collected by filtration, washed with water and 2-propanol and dried at 50° C overnight to afford 2.11 g of pure Moxonidine base in 85.0% yield having purity of 99.8%, [containing 0.05% of impurity II and 0.13% of impurity III].

References:

EP1894927,2008,A1 Location in patent:Page/Page column 9

67-56-1 Synthesis