ChemicalBook >> CAS DataBase List >>Moxonidine

Moxonidine

CAS No.
75438-57-2
Chemical Name:
Moxonidine
Synonyms
Cynt;LoMox;be5895;Nucynt;bdf5895;Norcynt;Moxonidin;MOXONIDINE;NorMoxocin;Physiotens
CBNumber:
CB8121013
Molecular Formula:
C9H12ClN5O
Molecular Weight:
241.68
MDL Number:
MFCD06795643
MOL File:
75438-57-2.mol
MSDS File:
SDS
Modify Date:2022-11-11 13:01:00

Moxonidine Properties

Melting point 217-219° (dec)
Boiling point 364.7±52.0 °C(Predicted)
Density 1.52±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
pka 7.11±0.10(Predicted)
form neat
color White to Almost white
Water Solubility 800.3mg/L(temperature not stated)
Merck 14,6293
InChIKey WPNJAUFVNXKLIM-UHFFFAOYSA-N
CAS DataBase Reference 75438-57-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII CC6X0L40GW
ATC code C02AC05

Pharmacokinetic data

Protein binding 7%
Excreted unchanged in urine 50-75%
Volume of distribution 1.8(L/kg)
Biological half-life 2-3 / 6.9 +/- 3.7

SAFETY

Risk and Safety Statements

RIDADR  UN 2811 6.1/PG III
WGK Germany  3
RTECS  UV6260290
HazardClass  6.1
PackingGroup  III

Moxonidine price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000226 Moxonidine European Pharmacopoeia (EP) Reference Standard 75438-57-2 y0000226 $138 2022-05-15 Buy
TCI Chemical M2660 Moxonidine >98.0%(T) 75438-57-2 200mg $126 2022-04-27 Buy
TCI Chemical M2660 Moxonidine >98.0%(T) 75438-57-2 1g $438 2022-04-27 Buy
Cayman Chemical 25639 Moxonidine ≥95% 75438-57-2 10mg $82 2022-04-27 Buy
Cayman Chemical 25639 Moxonidine ≥95% 75438-57-2 50mg $285 2022-04-27 Buy
Product number Packaging Price Buy
Y0000226 y0000226 $138 Buy
M2660 200mg $126 Buy
M2660 1g $438 Buy
25639 10mg $82 Buy
25639 50mg $285 Buy

Moxonidine Chemical Properties,Uses,Production

Description

Moxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.

Physical and Chemical Properties

ensity: 1.52g/cm3, boiling point:  364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.

Application

  • By stimulating the central presynaptic alpha 2-receptor and onset, and its antihypertensive effect of ACE inhibitors, calcium antagonists nifedipine and captopril similar. Treatment of essential hypertension.
  • The intervention of renal interstitial fibrosis can protect the kidney.

Preparation

5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.

Precautions

  • There may be dry mouth, fatigue and headache at the beginning of treatment, occasional dizziness, insomnia, and weakness in the legs and so on.
  • Sick sinus syndrome, the sinus node and atrioventricular Ⅱ-Ⅲ degree block, resting bradycardia (50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema patients should not use it.

References

https://en.wikipedia.org/wiki/Moxonidine

Description

Moxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.

Chemical Properties

White Solid

Originator

Beiersdorf (Germany)

Uses

Moxonidine is an antihypertensive agent.

Uses

Antihypertensive;Imidazoline receptor agonist

brand name

Cynt (Lilly); Nucynt (Lilly); Norcynt (Lilly);Physiotens.

Biological Activity

Mixed I 1 imidazoline receptor and α 2 -adrenergic agonist; displays 40-fold higher affinity for I 1 receptors versus α 2 -adrenoceptors. Centrally acting antihypertensive agent.

Clinical Use

Antihypertensive agent (centrally acting agonist at I1 receptor, imidazoline and alpha2 adrenoceptors)

Drug interactions

Potentially hazardous interactions with other drugs
None known

Metabolism

10-20% metabolised, predominantly to 4,5-dehydromoxonidine and to an aminomethanamidine derivative both of which are much less active than moxonidine. Moxonidine and its metabolites are almost entirely eliminated via the kidney. More than 90% of the dose is eliminated in the first 24 hours via the kidney, while approximately 1% is eliminated in the faeces

Moxonidine Preparation Products And Raw materials

Global( 204)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
+8615858145714 fandachem@gmail.com China 9361 55
Guangzhou PI PI Biotech Inc
+86-020-81716320 +86-18371201331 Sales@pipitech.com China 3635 55
GIHI CHEMICALS CO.,LIMITED
08657186217390 sales@gihichemicals.com CHINA 309 58
Wuhan Chemwonders Technology Inc.
027-85778276 info@chemwonders.com CHINA 176 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695 info@hnbon.com CHINA 26700 58
Synbest Biotech(Hangzhou) Co., Ltd
86-571-88737065 sales@synbestech.com CHINA 171 58
career henan chemical co
+86-0371-86658258 factory@coreychem.com China 29828 58
Shaanxi Dideu Medichem Co. Ltd
15319487004 1015@dideu.com China 3957 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 zzwenxi@126.com CHINA 13170 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-29-89586680 +8618192503167 1006@dideu.com China 9896 58

View Lastest Price from Moxonidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Moxonidine pictures 2021-10-20 Moxonidine
75438-57-2
US $100.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
Moxonidine pictures 2021-09-29 Moxonidine
75438-57-2
US $0.00 / Kg/Bag 50g 97.5%-102% 1000g WUHAN FORTUNA CHEMICAL CO., LTD
Moxonidine USP/EP/BP pictures 2021-08-11 Moxonidine USP/EP/BP
75438-57-2
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
  • Moxonidine pictures
  • Moxonidine
    75438-57-2
  • US $100.00 / KG
  • 99%
  • Hebei Lingding Biological Technology Co., Ltd
  • Moxonidine pictures
  • Moxonidine
    75438-57-2
  • US $0.00 / Kg/Bag
  • 97.5%-102%
  • WUHAN FORTUNA CHEMICAL CO., LTD

Moxonidine Spectrum

MOXONIDINE MOXONIDINE HCL 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin bdf5895 be5895 BDF-5895 HCL 4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL 4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE Moxonidin 4-Chloro-5-(2-imidazolin-2-ylamino)-6-methoxy-2-methylpyrimidine MOXONIDINE/4-CHLORO-N-(4,5-DIHYDRO-1H-2-IMIDAZOLYL)-6-METHOXY-2-METHYL-5-PYRAMINE 4-Chloro-N-(4,5-dihydro-1H-imidaml-2-y1)-6-methoxy-2-methyl-5-pyrimidinamine Cynt Physioterls 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine Norcynt (4-chloro-6-methoxy-2-methyl-pyrimidin-5-yl)-(4,5-dihydro-1H-imidazol-2-yl)amine 5-Pyrimidinamine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl- 2-(6-Chloro-4-Methoxy-2-MethylpyriMidin-5-ylaMino)-2-iMidazoline LoMox NorMoxocin Nucynt Physiotens Moxonidine-d3 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride 4-chloro-N-imidazolidin-2-ylidene-6-methoxy-2-methylpyrimidin-5-amine Moxonidine > Moxonidine CRS Moxonidine fandachem BDF5895 fandachem Moxonidine USP/EP/BP Moxonidine (BDF5895) Moxonidine 13CD3Q: What is Moxonidine 13CD3 Q: What is the CAS Number of Moxonidine 13CD3 Q: What is the storage condition of Moxonidine 13CD3 MoxonidineQ: What is Moxonidine Q: What is the CAS Number of Moxonidine Q: What is the storage condition of Moxonidine Q: What are the applications of Moxonidine 75438-57-2 C9H12ClN5O C9H12Cl5O Cardiovascular APIs API Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals API's