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Moxonidine

Description Physical and Chemical Properties Application Preparation Precautions References
Moxonidine
Moxonidine structure
CAS No.
75438-57-2
Chemical Name:
Moxonidine
Synonyms
Cynt;LoMox;be5895;Nucynt;bdf5895;Norcynt;Moxonidin;MOXONIDINE;NorMoxocin;Physiotens
CBNumber:
CB8121013
Molecular Formula:
C9H12ClN5O
Formula Weight:
241.68
MOL File:
75438-57-2.mol

Moxonidine Properties

Melting point:
217-219° (dec)
storage temp. 
Desiccate at +4°C
solubility 
Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
form 
neat
Merck 
14,6293
CAS DataBase Reference
75438-57-2(CAS DataBase Reference)

SAFETY

RIDADR  UN 2811 6.1/PG III
WGK Germany  3
RTECS  UV6260290
HazardClass  6.1
PackingGroup  III

Moxonidine price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000226 Moxonidine European Pharmacopoeia (EP) Reference Standard 75438-57-2 y0000226 $179 2018-11-23 Buy
TCI Chemical M2660 Moxonidine >98.0%(T) 75438-57-2 200mg $118 2018-11-22 Buy
TCI Chemical M2660 Moxonidine >98.0%(T) 75438-57-2 1g $413 2018-11-22 Buy
Cayman Chemical 25639 Moxonidine ≥95% 75438-57-2 10mg $75 2018-11-19 Buy
Cayman Chemical 25639 Moxonidine ≥95% 75438-57-2 50mg $263 2018-11-19 Buy

Moxonidine Chemical Properties,Uses,Production

Description

Moxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.

Physical and Chemical Properties

ensity: 1.52g/cm3, boiling point:  364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.

Application

  • By stimulating the central presynaptic alpha 2-receptor and onset, and its antihypertensive effect of ACE inhibitors, calcium antagonists nifedipine and captopril similar. Treatment of essential hypertension.
  • The intervention of renal interstitial fibrosis can protect the kidney.

Preparation

5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.

Precautions

  • There may be dry mouth, fatigue and headache at the beginning of treatment, occasional dizziness, insomnia, and weakness in the legs and so on.
  • Sick sinus syndrome, the sinus node and atrioventricular Ⅱ-Ⅲ degree block, resting bradycardia (50 beats/min), unstable angina, severe liver disease, progressive renal dysfunction, angioedema patients should not use it.

References

https://en.wikipedia.org/wiki/Moxonidine

Description

Moxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.

Chemical Properties

White Solid

Originator

Beiersdorf (Germany)

Uses

Moxonidine is an antihypertensive agent.

Uses

Antihypertensive;Imidazoline receptor agonist

brand name

Cynt (Lilly); Nucynt (Lilly); Norcynt (Lilly);Physiotens.

Biological Activity

Mixed I 1 imidazoline receptor and α 2 -adrenergic agonist; displays 40-fold higher affinity for I 1 receptors versus α 2 -adrenoceptors. Centrally acting antihypertensive agent.

Moxonidine Preparation Products And Raw materials

Raw materials

Preparation Products


Moxonidine Suppliers

Global( 126)Suppliers
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Wuhan Chemwonders Technology Inc.
027-85778276
027-85778276 info@chemwonders.com CHINA 121 58
Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
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020-81716319 Sales@pipitech.com CHINA 2543 55
GIHI CHEMICALS CO.,LIMITED
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J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
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3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15884 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24560 81
Jia Xing Isenchem Co.,Ltd 0573-85280080,18627885956
0573-85285100 isenchem@163.com,QQ:2446116053 China 9741 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595 sales@chemreagents.com United States 9922 62

75438-57-2(Moxonidine)Related Search:


  • MOXONIDINE
  • MOXONIDINE HCL
  • 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamin
  • bdf5895
  • be5895
  • BDF-5895 HCL
  • 4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL
  • 4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE
  • Moxonidin
  • 4-Chloro-5-(2-imidazolin-2-ylamino)-6-methoxy-2-methylpyrimidine
  • MOXONIDINE/4-CHLORO-N-(4,5-DIHYDRO-1H-2-IMIDAZOLYL)-6-METHOXY-2-METHYL-5-PYRAMINE
  • 4-Chloro-N-(4,5-dihydro-1H-imidaml-2-y1)-6-methoxy-2-methyl-5-pyrimidinamine
  • 75438-57-2
  • Cynt
  • Physioterls
  • 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-5-pyrimidinamine
  • 4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methylpyrimidin-5-amine
  • Norcynt
  • (4-chloro-6-methoxy-2-methyl-pyrimidin-5-yl)-(4,5-dihydro-1H-imidazol-2-yl)amine
  • 5-Pyrimidinamine, 4-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-6-methoxy-2-methyl-
  • 2-(6-Chloro-4-Methoxy-2-MethylpyriMidin-5-ylaMino)-2-iMidazoline
  • LoMox
  • NorMoxocin
  • Nucynt
  • Physiotens
  • Moxonidine-d3
  • 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride
  • 4-chloro-N-imidazolidin-2-ylidene-6-methoxy-2-methylpyrimidin-5-amine
  • C9H12ClN5O
  • C9H12Cl5O
  • API's
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API
  • Cardiovascular APIs
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