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Moxonidine

Description Physical and Chemical Properties Application Preparation Precautions References
Moxonidine
Moxonidine structure
CAS No.
75438-57-2
Chemical Name:
Moxonidine
Synonyms
Cynt;LoMox;be5895;Nucynt;bdf5895;Norcynt;Moxonidin;MOXONIDINE;NorMoxocin;Physiotens
CBNumber:
CB8121013
Molecular Formula:
C9H12ClN5O
Formula Weight:
241.68
MOL File:
75438-57-2.mol

Moxonidine Properties

Melting point:
217-219° (dec)
Boiling point:
364.7±52.0 °C(Predicted)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Very slightly soluble in water, sparingly soluble in methanol, slightly soluble in methylene chloride, very slightly soluble in acetonitrile.
form 
neat
pka
7.11±0.10(Predicted)
Water Solubility 
800.3mg/L(temperature not stated)
Merck 
14,6293
InChIKey
WPNJAUFVNXKLIM-UHFFFAOYSA-N
CAS DataBase Reference
75438-57-2(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
CC6X0L40GW
SAFETY
  • Risk and Safety Statements
RIDADR  UN 2811 6.1/PG III
WGK Germany  3
RTECS  UV6260290
HazardClass  6.1
PackingGroup  III

Moxonidine price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000226 Moxonidine European Pharmacopoeia (EP) Reference Standard 75438-57-2 y0000226 $190 2020-08-18 Buy
Sigma-Aldrich Y0000226 Moxonidine European Pharmacopoeia (EP) Reference Standard 75438-57-2 $190 2021-03-22 Buy
TCI Chemical M2660 Moxonidine >98.0%(T) 75438-57-2 200mg $120 2021-03-22 Buy
TCI Chemical M2660 Moxonidine >98.0%(T) 75438-57-2 1g $417 2021-03-22 Buy
Cayman Chemical 25639 Moxonidine ≥95% 75438-57-2 10mg $75 2021-03-22 Buy

Moxonidine Chemical Properties,Uses,Production

Description

Moxonidine, also known as Physiotens, is a highly selective imidazoline receptor agonist-Ⅰ by excitement ventrolateral medulla nucleus (RVLM)-Ⅰ type imidazoline receptor in the peripheral sympathetic nerve activity decreased. This receptor subtype is found in both the rostral ventro-lateral pressor and ventromedial depressor areas of the medulla oblongata.
Moxonidine therefore causes a decrease in sympathetic nervous system activity and, therefore, a decrease in blood pressure.
It is a new type of antihypertensive drug, commonly used in the treatment of essential hypertension. Compared to the older central-acting antihypertensives, moxonidine binds with much greater affinity to the imidazoline I1-receptor than to the α2-receptor. In contrast, clonidine binds to both receptors with equal affinity.
It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium channel blockers are not appropriate or have failed to control blood pressure.

Physical and Chemical Properties

ensity: 1.52g/cm3, boiling point:  364.7 °C at 760 mmHg, flash point: 174.3 °C, crystallization, melting point: 217-219 degrees Celsius.

Application

Preparation

5-amino-4,6-dichloro-2-methyl pyrimidine and 1-acetyl-2-imidazolin-2-one. The product, reacting with sodium methanol can produce moxonidine.

Precautions

References

https://en.wikipedia.org/wiki/Moxonidine

Description

Moxonidine, which is structurally related to clonidine, is a new centrally acting antihypertensive that acts as a stronger agonist at imidazole receptors and a weaker agonist at α2-adrenergic receptors than clonidine. It is also reported to have less side effects and a much reduced potential to produce a rebound in blood pressure on withdrawal. Clinically, moxonidine appears to have comparable antihypertensive efficacy with the ACE inhibitors and calcium antagonists.

Chemical Properties

White Solid

Originator

Beiersdorf (Germany)

Uses

Moxonidine is an antihypertensive agent.

Uses

Antihypertensive;Imidazoline receptor agonist

brand name

Cynt (Lilly); Nucynt (Lilly); Norcynt (Lilly);Physiotens.

Biological Activity

Mixed I 1 imidazoline receptor and α 2 -adrenergic agonist; displays 40-fold higher affinity for I 1 receptors versus α 2 -adrenoceptors. Centrally acting antihypertensive agent.

Moxonidine Preparation Products And Raw materials

Raw materials

Preparation Products


Moxonidine Suppliers

Global( 179)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Wuhan Chemwonders Technology Inc.
027-85778276
027-85778276 info@chemwonders.com CHINA 176 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
Synbest Biotech(Hangzhou) Co., Ltd
86-571-88737065
sales@synbestech.com CHINA 171 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29865 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 4149 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58

View Lastest Price from Moxonidine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Moxonidine
75438-57-2
US $100.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-09-29 Moxonidine
75438-57-2
US $0.00 / Kg/Bag 50g 97.5%-102% 1000g WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-11 Moxonidine USP/EP/BP
75438-57-2
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited

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