N-Methyl-4-nitro-N-phenylbenzenesulfonaMide, 97% synthesis
- Product Name:N-Methyl-4-nitro-N-phenylbenzenesulfonaMide, 97%
- CAS Number:64999-94-6
- Molecular formula:C13H12N2O4S
- Molecular Weight:292.31
Yield:64999-94-6 39%
Reaction Conditions:
with potassium permanganate in acetonitrile at 50; for 6 h;
Steps:
4.3. Typical procedure for the synthesis of 5
General procedure: A mixture of 4-methylbenzenesulfonyl chloride 4a (0.5 mmol), N,N-dimethylaniline 2a (1.5 mmol), KMnO4 (2 equiv.) and CH3CN (2.0 mL) was placed in a 25 mL reaction straight tube under air atmosphere. The tube was then placed in an oil bath, stirred and heated at 50 °C for 6 h. After cooling to room temperature, the system was flushed to Sand core funnel using dichloroethane (rinsing three times, VDCM < 50 mL), Vacuum filtration, and the volatile solvent was removed in vacuo. The crude product wa spurified over a column of silica gel (ethyl acetate/petroleum ether 1:20) to afford the white solid.
References:
Zhang, Zhang;Liu, Yong-Hong;Zhang, Xi;Wang, Xi-Cun [Tetrahedron,2019,vol. 75,# 19,p. 2763 - 2770]
