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N-Methylaniline

N-Methylaniline
N-Methylaniline structure
CAS No.
100-61-8
Chemical Name:
N-Methylaniline
Synonyms
ANILINOMETHANE;methylaniline-n;N-METHYLANILINE;n-methyl-anilin;N-METHYL-ANLINE;n’-BIcthylanilin;Methylphenylamine;MONOMETHYLANILINE;ORTHO TOLUIDINE MI;N-Methylaniline>
CBNumber:
CB2671945
Molecular Formula:
C7H9N
Formula Weight:
107.15
MOL File:
100-61-8.mol

N-Methylaniline Properties

Melting point:
-57 °C (lit.)
Boiling point:
196 °C (lit.)
Density 
0.989 g/mL at 25 °C (lit.)
vapor pressure 
0.5 hPa (20 °C)
refractive index 
n20/D 1.571(lit.)
Flash point:
174 °F
storage temp. 
Store below +30°C.
solubility 
water: slightly soluble30g/L
pka
4.84(at 25℃)
form 
Liquid
color 
Clear yellow to brown
PH
7.6 (1g/l, H2O, 20℃)
Odor
Moderate aniline-type.
Water Solubility 
30 g/L
Sensitive 
Air Sensitive
Merck 
14,6019
BRN 
741982
Henry's Law Constant
(x 10-5 atm?m3/mol): 1.19 at 25 °C (approximate - calculated from water solubility and vapor pressure)
Exposure limits
NIOSH REL: TWA 0.5 ppm (2 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 2 ppm (9 mg/m3); ACGIH TLV: TWA 0.5 ppm (adopted).
Stability:
Stability Combustible. Incompatible with strong oxidizing agents. Discolours upon exposure to air.
InChIKey
AFBPFSWMIHJQDM-UHFFFAOYSA-N
CAS DataBase Reference
100-61-8(CAS DataBase Reference)
EWG's Food Scores
1
NIST Chemistry Reference
Aniline, N-methyl-(100-61-8)
EPA Substance Registry System
N-Methylaniline (100-61-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H227-H400-H301+H311+H331-H373-H410-H301-H311-H331
Precautionary statements  P261-P273-P280-P301+P310-P311-P501-P210e-P260-P301+P310a-P405-P501a
Hazard Codes  T,N
Risk Statements  23/24/25-33-50/53
Safety Statements  28-36/37-45-60-61-28A
RIDADR  UN 2294 6.1/PG 3
WGK Germany  3
RTECS  BY4550000
8
Autoignition Temperature 500 °C
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29214200
Toxicity LD in rabbits (g/kg): 0.28 orally; in rabbits, cats (mg/kg): 24, 24 i.v. (Treon)
NFPA 704
2
0

N-Methylaniline price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.06096 N-Methylaniline for synthesis 100-61-8 100 mL $26.27 2021-03-22 Buy
Sigma-Aldrich 8.06096 N-Methylaniline for synthesis 100-61-8 1 L $80.47 2021-03-22 Buy
Sigma-Aldrich 236233 N-Methylaniline ≥99% 100-61-8 10g $92.4 2020-08-18 Buy
Sigma-Aldrich 49636 N-Methylaniline analytical standard 100-61-8 5 mL $147 2021-03-22 Buy
Sigma-Aldrich 236233 N-Methylaniline ≥99% 100-61-8 50g $357 2020-08-18 Buy

N-Methylaniline Chemical Properties,Uses,Production

Chemical Properties

N-Methylaniline is a yellow to light brown oily liquid with a weak, ammonia-like odor. Turns reddishbrown if left standing. The odor threshold is 1.7 ppm

Physical properties

Colorless to yellow to pale brown liquid with a faint, ammonia-like odor. Odor threshold concentration is 1.7 ppm (quoted, Amoore and Hautala, 1983).

Uses

N-Methylaniline is used as a solvent and in organic synthesis.

Uses

Chemical syntheses

Uses

Organic synthesis, solvent, acid acceptor.

Definition

ChEBI: A methylaniline that is aniline carrying a methyl substituent at the nitrogen atom.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 14, p. 1007, 1966 DOI: 10.1248/cpb.14.1007
Journal of the American Chemical Society, 107, p. 493, 1985 DOI: 10.1021/ja00288a037
Synthetic Communications, 13, p. 601, 1983 DOI: 10.1080/00397918308059535

Hazard

Toxic by ingestion, inhalation, and skin absorption. Methemoglobinemia and central nervous system impairment.

Health Hazard

Recommended Personal Protective Equipment: Approved respirator; rubber gloves; splash proof goggles; Symptoms Following Exposure: Inhalation causes dizziness and headache. Ingestion causes bluish discoloration (cyanosis) of lips, ear lobes, and fingernail beds. Liquid irritates eyes. Absorption through skin produces same symptoms as for ingestion; General Treatment for Exposure: INHALATION: remove victim to fresh air and call a physician at once; administer oxygen until physician arrives. INGESTION: give large amount of water; get medical attention at once. EYES or SKIN: flush with plenty of water for at least 15 min.; if cyanosis is present, shower with soap and warm water, with special attention to scalp and finger nails; remove any contaminated clothing; Toxicity by Inhalation (Threshold Limit Value): Data not available; Short-Term Inhalation Limits: Data not available; Toxicity by Ingestion: Data not available; Late Toxicity: Data not available; Vapor (Gas) Irritant Characteristics: Data not available; Liquid or Solid Irritant Characteristics: Data not available; Odor Threshold: Data not available.

Chemical Reactivity

Reactivity with Water No reaction; Reactivity with Common Materials: May attack some forms of plastic; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic fumes of NOx.

Potential Exposure

The material is used as an intermediate in organic synthesis, as a solvent and as an acid acceptor

Carcinogenicity

N-methyl aniline (1.95 g/kg of food) given together with sodium nitrite (1.0 g/l of drinking water) to Swiss mice resulted in a 17% incidence of lung adenomas and a 14% incidence of malignant lymphomas; there were no carcinogenic effects in animals treated with Nmethyl aniline alone, suggesting that in vivo nitrosation is necessary for forming carcinogenic nitrosamines.
In bacterial mutagenicity assays N-methyl aniline was negative with or without metabolic activation.

Environmental Fate

Soil. Reacts slowly with humic acids or humates forming quinoidal structures (Parris, 1980).

Shipping

UN2294 N-Methylaniline, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Purification Methods

Dry it with KOH pellets and fractionally distil it under vacuum. Acetylate, and the acetyl derivative is recrystallised to constant melting point (m 101-102o), then hydrolysed with aqueous HCl and distilled from zinc dust under reduced pressure. [Hammond & Parks J Am Chem Soc 77 340 1955, Beilstein 12 IV 241.]

Waste Disposal

Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal device.

N-Methylaniline Preparation Products And Raw materials

Raw materials

Preparation Products


N-Methylaniline Suppliers

Global( 291)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
SIMAGCHEM CORP
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shaobowang@simagchem.com CHINA 17453 58
Tianjin Zhongxin Chemtech Co., Ltd.
022-66880623
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Hebei Guanlang Biotechnology Co., Ltd.
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sales3@crovellbio.com China 5930 58
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0371-55170693
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View Lastest Price from N-Methylaniline manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 N-Methylaniline
100-61-8
US $10.00 / KG 1KG 99% 50 ton Hebei Crovell Biotech Co Ltd
2021-11-08 N-Methylaniline
100-61-8
US $10.00 / KG 1KG 99.9% 100MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
2021-07-09 N-methylphenylamine
100-61-8
US $2.00 / KG 1KG 99.9% 500 Ton/Tons per Month Hebei Xibaijie Biotechnology Co., Ltd.

N-Methylaniline Spectrum


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