N-Methyl-4-piperidinol synthesis
- Product Name:N-Methyl-4-piperidinol
- CAS Number:106-52-5
- Molecular formula:C6H13NO
- Molecular Weight:115.17
Yield:106-52-5 89%
Reaction Conditions:
with hydrogenchloride;palladium 10% on activated carbon;hydrogen in methanol;water; pH=2 - 3;
Steps:
1.1 Step 1) 1-methyl-4-piperidinol
A mixture of 4-piperidinol (1.16g, 10.07mmol) and 47% aqueous formaldehyde solution (10 mL) were dissolved in methanol (10 mL), and acidified with concentrated hydrochloricTo pH 2-3, to the system was added 10% Pd / C (300mg), two days the reaction system was kept under a hydrogen atmosphere. Completion of the reaction, filtered and the filtrate reducedPressure concentrated and the crude product purified by column chromatography (MeOH) to give a white solid (1.59g, 89%)
References:
CN105367582,2016,A Location in patent:Paragraph 0253; 0254; 0255
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