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ChemicalBook CAS DataBase List Tropic acid

Tropic acid synthesis

10synthesis methods
The process for preparing tropic acid which comprises reacting sodium phenylacetate with magnesium and isopropyl chloride, reacting the resulting sodium salt of alpha-carboxybenzylmagnesium chloride with formaldehyde, and hydrolyzing the resulting complex.
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid
3: sodium hydroxide / methanol

References:

Zhu, Dao-Yong;Zhang, Zhen;Mou, Xue-Qing;Tu, Yong-Qiang;Zhang, Fu-Min;Peng, Jin-Bao;Wang, Shao-Hua;Zhang, Shu-Yu [Advanced Synthesis and Catalysis,2015,vol. 357,# 4,p. 747 - 752]

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