| Identification | More | [Name]
1-METHANESULFONYL-PIPERAZINE | [CAS]
55276-43-2 | [Synonyms]
1-METHANESULFONYL-PIPERAZINE
1-(METHYLSULFONYL)PIPERAZINE
1-METHYLSULPHONYLPIPERAZINE
1-N-METHANESULFONYLPIPERAZINE
AKOS B003961
ART-CHEM-BB B003961
ART-CHEM-BB B022241
CHEMBRDG-BB 3003961
IFLAB-BB F2124-0764
TIMTEC-BB SBB007001
1-METHANESULFONYL-PIPERAZINE >98% | [Molecular Formula]
C5H12N2O2S | [MDL Number]
MFCD02153225 | [Molecular Weight]
164.23 | [MOL File]
55276-43-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
99 °C | [Boiling point ]
280.6±50.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Solid | [pka]
7.78±0.10(Predicted) | [color ]
White to Almost white | [Water Solubility ]
Slightly soluble in water. | [CAS DataBase Reference]
55276-43-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
1-(Methylsulfonyl)piperazine is employed as a intermediate for pharmaceutical and chemical research. | [Synthesis]
Step 2: Synthesis of 1-(methylsulfonyl)piperazine
A mixture of tert-butyl 4-(methylsulfonyl)piperazine-1-carboxylate (1.0 g, 3.79 mmol) with trifluoroacetic acid (TFA, 0.86 g, 7.58 mmol) in dichloromethane (CH2Cl2, 10 mL) was stirred for 2 hours at room temperature. After completion of the reaction, the mixture was concentrated under reduced pressure to afford 1-(methylsulfonyl)piperazine as a yellow oil (0.5 g, 80.52% yield). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 3.50-3.47 (m, 4H), 3.33-3.28 (m, 4H), 2.92 (s, 3H); ESI-MS m/z: 165 ([M + H]+). | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 375 - 379
[2] Patent: WO2010/141538, 2010, A1. Location in patent: Page/Page column 23
[3] Patent: WO2004/43950, 2004, A1. Location in patent: Page 152
[4] Patent: WO2005/51957, 2005, A1. Location in patent: Page/Page column 61-62
[5] Patent: WO2004/85425, 2004, A1. Location in patent: Page 98 |
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