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description Chemical properties Uses Physiological functions Synthesis of Melatonin

CAS No. 73-31-4
Chemical Name: Melatonine
Synonyms: MLT;MLK7;MLT1;primex;mlklak;Circadin;Melovine;melotonin;MELATONIN;MELATONINE
CBNumber: CB5364927
Molecular Formula: C13H16N2O2
Formula Weight: 232.28
MOL File: 73-31-4.mol
Melatonine Property
Melting point : 116.5-118 °C(lit.)
Fp : 9℃
storage temp. : -15°C
solubility : Soluble in ethanol to at least 50mg/ml
form : Powder
color : white to off-white
Merck : 5816
CAS DataBase Reference: 73-31-4(CAS DataBase Reference)
NIST Chemistry Reference: Melatonin(73-31-4)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : T,F
Risk Statements : 60-39/23/24/25-23/24/25-11
Safety Statements : 24/25-99-53-45-36/37-16-7
RIDADR : UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany : 2
RTECS : AC5955000
F : 8-10-23
HS Code : 29379000
Hazardous Substances Data: 73-31-4(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Melatonine Chemical Properties,Usage,Production

Melatonin is a hormone secreted by the pineal gland, and its chemical structure was 5-methoxy-N-acetyl tryptamine, the physiological function of inhibiting gonad, thyroid, adrenal gland, parathyroid gland and pituitary function, inhibit precocious puberty, reduce pituitary Melanotropin secretion; and has a central nervous system function, can improve the convulsion the threshold, cause drowsiness. When pinealectomy after the animal experiment showed hyperplasia of the glands, weight increase, especially sex and sexual organs of immature rats early, pituitary secretion of LH and FSH increased, increasing secretion of thyroid and adrenal cortex hormone melatonin. More reduced pituitary MSH and whiten the skin of this role. Effects on the central nervous system, in the human EEG showed slow rhythm, increased seizure threshold, sleepiness, but does not affect their behavior and personality, of temporal lobe epilepsy and Ba Jinsen disease can reduce the motor nerve Abnormal EEG changes.
Chemical properties
White or almost white crystalline powder.
1. Melatonin can be used as medicine health care products, so as to enhance people’s immune function, preventing aging and back to youth. What’s more, it is also a kind of natural “sleeping pill”.
2. Melatonin is a kind of hormone secreted by pineal body of pituitary gland in the body. The amount of melatonin has something to do with light. The weaker the light is, the more the melatonin is, whereas the less. In addition, it is helpful to one’s sleep.
3. Biochemical research.
Physiological functions
1. The effect to brain: the melatonin obtained by brain mainly gathers in midbrain and hypothalamus and it adds the activity of brain pyridoxal kinase, thus promoting glutamic acid decarboxylation to γ-amino butyric acid, 5-hydroxytryptophane decarboxylation to 5-hydroxytryptamine, both of which can inhibit the increase of the neurotransmitter content and have an effect of adjustment and mitigation on central nervous system.
2. The effect to hypothalamus and pituitary: materials like polypeptide produced by pineal body still have thyrotropin-releasing hormone(TRH) and luteinizing hormone releasing hormone(LRH) which are same with what hypothalamus produces except AVT. After injection of melatonin, gonadotropin (GnH)(FSH,LH) and melanocyte stimulating hormone(MSH) are lowered while growth hormone increases. Cutting pineal gland will cause pituitary hypertrophy, increase pituitary secretion and lower prolactin(PRL) and antidiuretic hormone (ADH).
3. The relation to gonad: melatonin has an inhibitory effect on the reproductive system. Clinically, main cytoma of pineal body can lead to pubertal delay and when teratoma appears in pineal body, it may result in sexual precocity because main cells are excluded. Ambient light and sympathetic nerve can affect the function of the reproductive system by inhibiting the synthesis and release of melatonin in pineal gland.
4. The relation to thyroid: by injecting melatonin, thyroid secretion will decrease. This may be caused through the inhibition of the hypothalamus release and Thyroid Stimulating Hormone (TSH) secretion of pituitary, hence holding back the function of thyroid.
5. The relation to adrenal cortex: melatonin has a strong inhibitory effect on adrenal cortex. If we inject pineal body extracts to healthy people, we will find that their aldosterone secretion and 17-ketosteroid output will decrease.
6. The relation to pancreatic island: melatonin can lower blood glucose and increase sugar tolerance. In conclusion, pineal gland can assist pituitary to jointly adjust endocrine function and play an vital role in keeping relatively constant in body environment and controlling some endocrine function, especially for gonad.
Synthesis of Melatonin
Pineal cells obtain tryptophan from blood circulation and become 5-hydroxytryptophane catalyzed by hydroxylase and 5-hydroxytryptophane turns into 5-hydroxytryptamine after decarboxylated by decarboxylase. There are three possible changes for 5-hydroxytryptamine: for the first part it may turn into 5-hydroxyl-benzpyrole acetic acid when deaminated by monoamine oxidase; for another part, some 5-hydroxytryptamine will leave the pineal cell and be taken in by sympathetic nerve ending and stored with neurotransmitter and noradrenalin; for the remaining part, the 5-hydroxytryptamine will be acetylated by N-acetyl-5-hydroxy tryptamine transferase and then be o-methoxy by hydroxylation indole-o-methyl converzyme, finally forming melatonin. After being synthesized, melatonin will be released by cells and enter into blood circulation through cerebrospinal fluid or directly, where noradrenalin may strengthen the synthesis, the speed of which depends on activity of hydroxylase in liver microsomes. Catalyzed by the hydroxylase, 6-hydroxylmelatonin is formed, soon afterwards it combines with glucuronic acid and sulfate, excreting through urine.
Chemical Properties
Off-White Powder
sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger
Immunostimulant;Melatonin receptor ligand
Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.
Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase
ChEBI: A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen atom is replaced by a 2-(5-methoxy-1H-indol-3-yl)ethyl group. It is a hormone secreted by the pineal gland in humans.
Biological Activity
Endogenous hormone that acts as an agonist at melatonin receptors MT 1 and MT 2 . Exhibits a prominent role in the control of circadian rhythm, displays immunomodulatory activity and acts as a powerful antioxidant in vivo .
Melatonine Preparation Products And Raw materials
Raw materials
Preparation Products
Melatonine Suppliers      Global( 331)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Shanghai ChengShao Biological Technology Co., Ltd. 021-61847300 13341622919
021-61847300 China 4815 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885
021-65675885 China 1999 58
Hefei TNJ Chemical Industry Co.,Ltd. +86 (551) 65418684 65418696
+86 (551) 65418697 China 1944 62
Wuhan HengWo Technology Co., Ltd. 0571-87963082 18062502932
0571-87963082 China 2043 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96831 76
Nanjing Elegant Nutraceuticals Co., Ltd 0086-25-83241153, 83241163
0086-25-83241173 China 51 55
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40403 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 Germany 3589 66
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 China 15950 69
future industrial shanghai co., ltd 021-61552785,400-0066-400
021-55660885 China 2091 65
73-31-4(Melatonine)Related Search:
2-(2-Aminoethylamino)ethanol 2,4-Pentanedione Acetyl chloride Ethyl formate 3-Methoxybenzaldehyde Ethyl acetate Etanol Acetamide Ethyl propionate 4'-Methoxyacetophenone Ethyl acrylate p-Anisaldehyde Diethyl ether (Trifluoromethoxy)benzene p-Anisidine Ethylbenzene N-ACETYL-L-TYROSINE ETHYL ESTER Tetraacetylethylenediamine
Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- Acetamide,N-[2-(5-methoxy-1H-indol-3-yl)ethyl] Melatonin(N-Acetyl-5-methoxytryptamine) BioChemical 3-N-Acetyl-5-methoxyl tryptamine Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. MELATONIN, 99.5+% MELATONIN F&D VERSION FOR VETERINARY US MELATONIN CRYSTALLINE MELATONIN,(SECONDARY STANDARD) MELATONIN,(PRIMARY STANDARD) MELATONIN, HPLC ANALYSIS KIT MELATONIN,1.0MG/MLINMETHANOL MELATONIN,POWDER N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ethanamide MELATONIN (MLT) primex Heterocyclic Series N-Acetyl-5-Methoxytryptamine also Melatonine pharmaceutical grade Melatonin Heterocycles series Melatonin 99.0%min Indoles Tryptamines Nutritional Supplements Intermediates & Fine Chemicals Pharmaceuticals Circadin Melovine Melatonin ,99% Melatonin receptor 3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole N-Acetyl-5-methoxytriptamine MELATONIN (M) Melatonine,99% Melatonin ,98% Melatonin (100 mg) (AS) Melatonin (AS) Amines Heterocycles Melatonins Alkaloid Bioactive Small Molecules Building Blocks C13 to C27 Cell Biology Cell Signaling and Neuroscience Chemical Synthesis Heterocyclic Building Blocks M Neurobiology Neuroscience Nutrition Research Pharmacologicals Phytochemicals by Chemical Classification Melatonine,N-(2-(5-Methoxyindol-3-yl)ethyl)acetaMide MELATONINE FOR SYNTHESIS 1 G
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