Amoxicillin trihydrate
- CAS No.
- 61336-70-7
- Chemical Name:
- Amoxicillin trihydrate
- Synonyms
- AMOXYCILLIN TRIHYDRATE;AMOXICILIN TRIHYDRATE;Amoxicillin trihydrate for performance verification CRS;Am 7;Amodex;A-Gram;Ardine;PeniMox;HelvaMox;AmoxiciL
- CBNumber:
- CB6690306
- Molecular Formula:
- C16H21N3O6S
- Molecular Weight:
- 383.42
- MDL Number:
- MFCD00072029
- MOL File:
- 61336-70-7.mol
- MSDS File:
- SDS
| Melting point | >200°C (dec.) |
|---|---|
| alpha | D20 +246° (c = 0.1) |
| refractive index | 302 ° (C=0.1, H2O) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in fatty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides. |
| color | White to Off-White |
| Water Solubility | Soluble in water at 3.4mg/ml. |
| Merck | 14,577 |
| JECFA Number | 85 |
| BRN | 7507120 |
| CAS DataBase Reference | 61336-70-7(CAS DataBase Reference) |
| FDA UNII | 804826J2HU |
| EPA Substance Registry System | Amoxicillin trihydrate (61336-70-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H334 |
| Precautionary statements | P261-P272-P280-P284-P302+P352-P333+P313 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 42/43 |
| Safety Statements | 36-36/37-22 |
| WGK Germany | 2 |
| RTECS | XH8300000 |
| HS Code | 29411000 |
| Toxicity | LD50 ipr-rat: 2870 mg/kg KSRNAM 7,3040,73 |
Amoxicillin trihydrate price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BP748 | Amoxicillin impurity standard British Pharmacopoeia (BP) Reference Standard | 61336-70-7 | 25MG | $238 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP019 | Amoxicillin trihydrate British Pharmacopoeia (BP) Reference Standard | 61336-70-7 | 500MG | $233 | 2024-03-01 | Buy |
| Sigma-Aldrich | 31586 | Amoxicillin trihydrate VETRANAL | 61336-70-7 | 250mg | $83.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1031503 | Amoxicillin United States Pharmacopeia (USP) Reference Standard | 61336-70-7 | 200mg | $436 | 2024-03-01 | Buy |
| TCI Chemical | A2099 | Amoxicillin Trihydrate >98.0%(T) | 61336-70-7 | 5g | $35 | 2024-03-01 | Buy |
Amoxicillin trihydrate Chemical Properties,Uses,Production
Description
Amoxicillin was synthesized by Beecham Research Laboratories in 1968. A hydroxyl group was introduced on the benzene ring of ampicillin. Amoxicillin shows about a twofold higher serum concentration than ampicillin when administered orally. It was shown by double-blind comparative studies with ampicillin that amoxicillin was as effective as ampicillin when administered at half the dose of ampicillin.
Chemical Properties
White to Off-White Solid
Originator
Arnoxil,Bencard,UK,1972
Uses
Semi-synthetic antibiotic related to Penicillin. Antibacterial.
Uses
Amoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties. It is used for treatment of a variety of bacterial infections. It is used as a pharmaceutical product as a antibiotic agent, anti-infective drug raw materials.
Definition
ChEBI: A hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections.
Manufacturing Process
Ethyl chlorocarbonate (2.2 ml) was added to an ice cold solution of O,N-dibenzyloxycarbonyl-p-oxy-dl-α-aminophenylacetic acid (10 grams) and
triethylamine (3.85 ml) in dry acetone (193 ml). The mixture was stirred at
0°C for 5 minutes during which triethylamine hydrochloride precipitated. The
suspension was cooled to -30°C and stirred vigorously while adding as rapidly
as possible an ice cold solution of 6-aminopenicillanic acid (5.85 grams) in 3%
aqueous sodium bicarbonate (193 ml), the temperature of the mixture never
being allowed to rise above 0°C. The resulting clear solution was stirred for 30
minutes at 0°C, and then for a further 30 minutes, without external cooling,
and finally extracted with diethyl ether (3 x 200 ml) only the aqueous phase
being retained.
This aqueous solution was brought to pH 2 by the addition of hydrochloric acid
and the 6-(O,N-dibenzyloxycarbonyl-p-oxy-dl-α-
aminophenylacetamido)penicillanic acid so liberated was extracted into diethyl
ether (50 ml and 2 portions of 30 ml). The ether phase was washed with
water (3 x 5 ml) and the water washings were discarded.
Finally, the penicillin was converted to the sodium salt by shaking the ether
solution with sufficient 3% sodium bicarbonate to give a neutral aqueous
phase, separating the latter and evaporating it at low pressure and
temperature below 20°C. The product was finally dried over phosphorus
pentoxide in vacuo to give sodium 6-(O,N-dibenzyloxycarbonyl-p-oxy-dl-α-
aminophenylacetamido)-penicillanate (9.2 grams).
A suspension of palladium on calcium carbonate (36 grams of 5%) in water
(150 ml) was shaken in an atmosphere of hydrogen at room temperature and
atmospheric pressure for 1 hour. A neutral solution of sodium 6-(O,Ndibenzyloxycarbonyl-
p-oxy-dl-α-aminophenylacetamido)penicillanate (9
grams) in water (100 ml) was then added and shaking in hydrogen was
resumed for one hour. The suspension was then filtered and the collected
catalyst was washed well with water without being allowed to suck dry
between washings. The combined filtrate and washings were then brought to
pH 6.5 with dilute hydrochloric acid and evaporated to dryness at reduced
pressure and temperatures below 20°C. The product was finally dried over
phosphorus pentoxide in vacuo to give a solid (5.4 grams) containing 6-(phydroxy-
dl-α-aminophenylacetamido)penicillanic acid.
brand name
Amoxil (GlaxoSmithKline); Dispermox (Ranbaxy); Larotid (GlaxoSmithKline); Trimox (Apothecon) [Name previously used: Amoxycillin.].
Therapeutic Function
Antibacterial
Contact allergens
Amoxicillin is both a topical and a systemic sensitizer. Topical sensitization occurs in health care workers. Systemic drug reactions are frequent, such as urticaria, maculo-papular rashes, baboon syndrome, acute generalized exanthematous pustulosis, or even toxic epidermal necrosis. Cross-reactivity is common with ampicillin, and can occur with other penicillins.
Safety Profile
Moderately toxic. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.
Amoxicillin trihydrate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 525 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 359 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8619133911216 | fanfan@kangcang.com.cn | China | 340 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 893 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Related articles
- Pharmacokinetics of amoxicillin trihydrate
- Amoxicillin trihydrate is a white to off-white free flowing crystalline powder.
- Sep 2，2022
View Lastest Price from Amoxicillin trihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | Amoxicillin Trihydrate
61336-70-7
|
US $9.00-70.00 / g | 10g | 99% | 10 tons | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-03-23 | Amoxicillin Trihydrate
61336-70-7
|
US $0.00 / kg | 1kg | 99% | 10tons | Shaanxi TNJONE Pharmaceutical Co., Ltd | |
 |
2024-03-21 | Amoxicillin trihydrate
61336-70-7
|
US $0.00-0.00 / KG | 1KG | 99 | 10 tons | Shanghai Affida new material science and technology center |
-
- Amoxicillin Trihydrate
61336-70-7
- US $9.00-70.00 / g
- 99%
- Hebei Kangcang new material Technology Co., LTD
-
- Amoxicillin Trihydrate
61336-70-7
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Amoxicillin trihydrate
61336-70-7
- US $0.00-0.00 / KG
- 99
- Shanghai Affida new material science and technology center