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Omeprazole

Indications and Usage Mechanisms of Action Drug Interactions Adverse reactions Preparation
Omeprazole
Omeprazole
CAS No.
73590-58-6
Chemical Name:
Omeprazole
Synonyms
miol;elgam;zimor;ANTRA;LOSEC;aulcer;prysma;ulcsep;MEPRAL;ZOLTUM
CBNumber:
CB8160492
Molecular Formula:
C17H19N3O3S
Formula Weight:
345.42
MOL File:
73590-58-6.mol

Omeprazole Properties

Melting point:
156°C
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: 0.5 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml).
Merck 
6845
Stability:
Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.
CAS DataBase Reference
73590-58-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,T,F
Risk Statements  36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-36-37/39-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  DD9087000
Hazardous Substances Data 73590-58-6(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Omeprazole price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1478505 Omeprazole United States Pharmacopeia (USP) Reference Standard 73590-58-6 200mg $348.4 2017-11-08 Buy
Sigma-Aldrich 19329 Omeprazole analytical reference material 73590-58-6 50mg $57.7 2017-11-08 Buy
TCI Chemical O0359 Omeprazole >98.0%(HPLC)(T) 73590-58-6 5g $86 2017-11-08 Buy
TCI Chemical O0359 Omeprazole >98.0%(HPLC)(T) 73590-58-6 25g $306 2017-11-08 Buy
Alfa Aesar J62860 Omeprazole, 98% 73590-58-6 1g $48.5 2017-11-08 Buy

Omeprazole Chemical Properties,Uses,Production

Indications and Usage

Omeprazole is a proton pump inhibitor used to treat diseases like gastroesophageal reflux disease (GERD), used for gastric and duodenal ulcers, reflux or erosive esophagitis, and Zollinger-Ellison syndrome. It is also effective for gastric and duodenal ulcers that are ineffective with H2 receptor antagonists. Injections of Omeprazole can also be used for: 1 gastrointestinal bleeding, such as peptic and anastomic ulcer bleeding, and the prevention of severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and gastric surgery caused by upper intestinal bleeding; 2 acute gastric mucosal damage complicated by stress or nonsteroidal anti-inflammatory drugs; 3 general anesthesia, post-surgery, or coma patients, to prevent acid reflux and aspiration pneumonia; 4 Combined with amoxicillin and clarithromycin, or with metronidazole and clarithromycin, it can effectively kill Helicobacter pylori (Hp).

Mechanisms of Action

Omeprazole is a proton pump inhibitor which can specifically act on gastric parietal cell proton pump sites and transform into the active form of sulfonamide, then irreversibly binds to the proton pumps through disulfide bonds, generating a sulfonamide and proton pump compound (H + -K + -ATP), thereby inhibiting the enzymatic activity, preventing the H+ in parietal cells from being transported to the stomach cavity. It has a strong and persistent inhibitory role on gastric acid secretion caused by basal gastric acid and pentapeptide gastric acid secretions, greatly reducing gastric acid within the gastric juice. Rapid, reversible, and no H2 antagonist-induced psychiatric side effects.

Drug Interactions

Adverse reactions

Omeprazole is well tolerated, and most adverse reactions are mild and reversible.

Preparation

Chemical Properties

White Crystalline Solid

Uses

Binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative

Uses

diuretic, sweetener, diagnostic aid

Uses

A selective proton pump and CYP inhibitor

Uses

Omeprazole Pellets are used in the treatment of Gastroesophageal reflux disease (GERD): A condition in which backward flow of acid from the stomach causes heartburn and injury of the food pipe (esophagus)

Definition

ChEBI: A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Biological Activity

H + ,K + -ATPase inhibitor (IC 50 = 5.8 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.16 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro . Also inhibits CYP2C19, CYP2C9 and CYP3A (K i values are 3.1, 40.1 and 84.4 μ M respectively) and blocks swelling-dependent chloride channels (ICIswell).

Omeprazole Preparation Products And Raw materials

Raw materials

Preparation Products


Omeprazole Suppliers

Global( 312)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3230 55
3600Chem 027-59207852 51787268 18827367472
027-59524646 sales@3600chem.com China 4996 55
WUHAN YUANCHENG GONGCHUANG TECHNOLOGY CO.,LTD 021 6858 0971/18964558747
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Guangzhou Kafen Biotech Co.,Ltd 020-31121484 18027468163 QQ:2355327168
020-31121510 gy@yccreate.com China 4346 55
Wuhan Hezhong Bio-chemical Manufacture co ltd 021-68580715 / 18930710487
nikki@pharm-china.com China 2017 55
ChemStrong Scientific Co.,Ltd 0755 66853366
0755 28363542 sales@chem-strong.com; China 10145 56
Wuhai Shuou Technology Co., Ltd. 18872220797 / QQ:2355327072
027-88211932 liul@yuanchengtech.com China 3203 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96831 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40403 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3589 66

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