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2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Structure
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl structure
CAS No.
657408-07-6
Chemical Name:
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
Synonyms
98% SPhos;Dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane;dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane;6´NS-PHOS;SPhos 97%;SPhos, >=98%;REF DUPL: S-PHOS;-diMethoxybiphenyl;S-Phos, ChemDose(TM) tablets
CBNumber:
CB8634850
Molecular Formula:
C26H35O2P
Molecular Weight:
410.53
MDL Number:
MFCD05861611
MOL File:
657408-07-6.mol
MSDS File:
SDS
Last updated:2023-06-09 17:34:24
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2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Properties

Melting point 164-166°C
Boiling point 513.3±40.0 °C(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Chloroform
form crystal
color white
Sensitive Air Sensitive
InChIKey VNFWTIYUKDMAOP-UHFFFAOYSA-N
FDA UNII XI1MQ32186

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H351
Precautionary statements  P280
Hazard Codes  Xn
Risk Statements  40
Safety Statements  24/25-36/37
WGK Germany  3
TSCA  No
HS Code  2931499090
NFPA 704
0
2 0

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 901906 SPhos 95% 657408-07-6 1G $31.44 2024-03-01 Buy
Sigma-Aldrich 901906 SPhos 95% 657408-07-6 5G $143 2024-03-01 Buy
Sigma-Aldrich 901906 SPhos 95% 657408-07-6 25G $270.4 2024-03-01 Buy
Sigma-Aldrich 932191 SPhos ChemBeads 657408-07-6 1g $287 2024-03-01 Buy
Sigma-Aldrich 901906 SPhos 95% 657408-07-6 250G $736 2024-03-01 Buy
Product number Packaging Price Buy
901906 1G $31.44 Buy
901906 5G $143 Buy
901906 25G $270.4 Buy
932191 1g $287 Buy
901906 250G $736 Buy

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Chemical Properties,Uses,Production

Uses

SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. 
SPhos may be used as a ligand in the following processes:
• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.

Reactions

  1. Ligand/palladium catalyst for general Suzuki-Miyaura cross-coupling reactions.
  2. Ligand/palladium catalyst for the Suzuki-Miyaura coupling of aryltrifluoroborates with aryl chlorides.
  3. Ligand/palladium catalyst for the Suzuki-Miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
  4. Ligand/palladium catalyst for the Kumada-Corriu cross-coupling reaction.
  5. Ligand/palladium catalyst for the borylation of aryl halides with pinacol borane.
  6. Suzuki couplings involving amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenyl glycine, tyrosine and tryptophan.
  7. Synthesis of substituted adamantylzinc reagents using Mg-insertion in the presence of zinc chloride.
  8. Highly efficient catalyst for the palladium-catalyzed Suzuki-Miyura reaction of heteroaryl halides and heteroaryl boronic acids
  9. and esters.
Reactions of 657408-07-6

Chemical Properties

White solid

Uses

suzuki reaction

Uses

S-Phos is a catalyst that is used in the preparation of thiadiazoles as DGAT1 inhibitors with potential in metabolic diseases treatment.

General Description

SPhos [2-Dicyclohexylphosphino-2′, 6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl synthesis

694-80-4
151-10-0
16523-54-9
657408-07-6
Synthesis of 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl from 2-Bromochlorobenzene and 1,3-Dimethoxybenzene and Dicyclohexylchlorophosphine

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Preparation Products And Raw materials

Raw materials

Dicyclohexylchlorophosphine 1,3-Dimethoxybenzene Tetrahydrofuran 1,2-Dibromobenzene Ethyl acetate
PETROLEUM ETHER Magnesium n-Butyllithium

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Preparation Products

Boronic acid, B-(6-phenyl-4-dibenzofuranyl)- SPhos Pd G1, Methyl t-Butyl Ether Adduct

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Suppliers

Global( 390)Suppliers
Supplier Tel Email Country ProdList Advantage
XINXIANG RUNYU MATERIAL CO., LTD.
+86-13592593621; +8613592593621 sales@runvmat.com China 415 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15933 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
AB PharmaTech,LLC 		323-480-4688 United States 989 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2968 58
Supplier Advantage
XINXIANG RUNYU MATERIAL CO., LTD.
58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
AB PharmaTech,LLC 		55
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Jinan Finer Chemical Co., Ltd 		58

View Lastest Price from 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl pictures 2024-04-29 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
657408-07-6
 US $0.00 / Kg/Drum 1KG 99% 200mt Jinan Finer Chemical Co., Ltd
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl pictures 2023-07-27 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
657408-07-6
 US $0.00-0.00 / KG 1KG 0.99 500kg XINXIANG RUNYU MATERIAL CO., LTD.
SPHOS pictures 2023-06-10 SPHOS
657408-07-6
 US $5.00-2.00 / KG 1KG 99% 10000kg Hebei Guanlang Biotechnology Co,.LTD
  • SPHOS pictures
  • SPHOS
    657408-07-6
  • US $5.00-2.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co,.LTD

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Spectrum

2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl(657408-07-6)1HNMR2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl(657408-07-6)31PNMR2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl(657408-07-6)FT-IR

657408-07-6(2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl)Related Search:

X-PHOS 2-(Dicyclohexylphosphino)-2'-methylbiphenyl 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl Diphenyldimethoxysilane Dimethyldimethoxysilane
trans-Bifenthtin Bifendate 1,1-Dimethoxyethane 2-(Dicyclohexylphosphino)biphenyl 2-DICYCLOHEXYLPHOSPHINO-2',6'-DIISOPROPOXYBIPHENYL
DI-N-PENTYLPHENYLPHOSPHINE 2-(DICYCLOHEXYLPHOSPHINO)-2'-HYDROXYBIPHENYL DICYCLOHEXYLPHOSPHINE CYCLOHEXYLPHOSPHINE Dicyclohexylphenylphosphine
2'-DICYCLOHEXYLPHOSPHINO-2,6-DIMETHOXY-3-SULFONATO-1,1'-BIPHENYL HYDRATE SODIUM SALT 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl

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2-Dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl ,98% 2-Dicyclohexylphosphino-2', 6-diMethoxybihenyl 2-DicyclohexylphosphiNA-2',6'-diMethoxybiphenyl Dicyclohexyl(2',6'-diMethoxy-[1,1'-biphenyl]-2-yl)phosphine SPhos 97% 2-Dicyclohexylphosphino-2',6'-diMethoxybiphenyl, 6'-diMethoxybiphenyl 2 - dicyclohexyl phosphine - 2 ', 6 '- diMethoxy - 1, 1' - two PCB 2-Dicyclohexylphosphino-2',6'- 2-Dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl,98% Sphos 2-(Dicyclohexylphosphanyl)-2',6'-dimethoxybiphenyl S-Phos, ChemDose? tablets dicyclohexyl({2-[(2,6-dimethoxyphenyl)methyl]phenyl}methyl)phosphane 2-Dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl, min. 98% Phosphine,dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2-yl)- SPhos, >=98% 2-Dicyclohexylphosphino-2’,6’-dimethoxy-1,1’-biphenyl (S-Phos) 2-DICYCLOHEXYLPHOSPHINO-2',6'-DIMETHOXY-1,1'-BIPHENYL, MIN. 98% S-PHOS 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl, min. 98% S-Phos impregnated tablets, ChemDose(R), S-Phos tablets, 2-Dicyclohexylphosphino-2μ,6μ-dimethoxybiphenyl impregnated tablets S-Phos, ChemDose(R) tablets 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 6´ 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl, 98+% REF DUPL: S-PHOS 2-Dicyclohexylphosphino-2',6'-dimethoxybipheny Dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine 2-Dicyclohexylphosphino-2´ -diMethoxybiphenyl S-PHOS, 2-Dicyclohexylphosphino-2,6-di-Methyloxy-1,1-biphenyl Dicyclohexyl(2',6'-diMethoxy-[1,1'-biphenyl S-phos, 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Sphos Sphos / 2-Dicyclohexylphosphino-2'',6''-dimethoxy-1,1''-biphenyl 2-(Dicyclohexylphosphanyl)-2',6'-dimethoxybiphenyl 98% 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 657408-07-6 250g -Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 2-DICYLOHEXYLPHOSPHINO-2,6-DIMETHOXYBIPHENYL phosphino-2’,6’-dimethoxybiphenyL phosphino-2',6'-dimethoxy-1,1'-biphenyL NS-PHOS S-Phos, ChemDose(TM) tablets 2-Dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl,min.98% 2-Dicyclohexyphosphino-2'6'-dimethoxy-1,1'-biphenyl (Sphos) S-Phos (2-Dicyclohexylphosphino-2,6-Dimethoxybiphenyl) extrapure, 98% 98% SPhos Dicyclohexyl-[2-(2,6-dimethoxyphenyl)phenyl]phosphane dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane Dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine(S-PHOS) 2-DICYCLOHEXYLPHOSPHINO-2',6'-DIMETHOXY-1,1'-BIPHENYL 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl(Sphos) Dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine dicyclohexyl(2',6'-dimethoxy-[1,1'-biphenyl]-2-yl)phosphane Dicyclohexyl(2',6'-dimethoxybiphenyl-2-yl)phosphine 657408-07-6 C26H35O2P C28H39O2P Phosphines