XANTHOTOXOL
- CAS No.
- 2009-24-7
- Chemical Name:
- XANTHOTOXOL
- Synonyms
- 9-hydroxy-;NSC 401269;XANTHOTOXOL;AKOS 210-08;Xanthotoxol?, BR;8-HYDROXYPSORALEN;Xanthotoxol (6CI);8-hydroxypsoralene;XANTHOTOXOL IMpurity;XANTHOTOXOL(RG)(CALL)
- CBNumber:
- CB9438695
- Molecular Formula:
- C11H6O4
- Molecular Weight:
- 202.16
- MDL Number:
- MFCD00017408
- MOL File:
- 2009-24-7.mol
| Melting point | 250°C |
|---|---|
| Boiling point | 428.1±45.0 °C(Predicted) |
| Density | 1.526±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 5.74±0.20(Predicted) |
| color | Light Beige to Dark Brown |
| LogP | 1.405 (est) |
| FDA UNII | 8RL486L8A5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 20-45-24/25 | |||||||||
| RIDADR | 2810 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
XANTHOTOXOL price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27801 | Xanthotoxol | 2009-24-7 | 5mg | $76 | 2024-03-01 | Buy |
| Cayman Chemical | 27801 | Xanthotoxol | 2009-24-7 | 25mg | $315 | 2024-03-01 | Buy |
| Cayman Chemical | 27801 | Xanthotoxol | 2009-24-7 | 10mg | $135 | 2024-03-01 | Buy |
| TRC | X742500 | Xanthotoxol | 2009-24-7 | 1g | $60 | 2021-12-16 | Buy |
| Usbiological | 292055 | Xanthotoxol | 2009-24-7 | 1g | $319 | 2021-12-16 | Buy |
XANTHOTOXOL Chemical Properties,Uses,Production
Description
Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities. It inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM, respectively). Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA). It is nematocidal against M. incognita (IC50 = 68 mg/L). In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively. It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.
Chemical Properties
Dark Brown Solid
Uses
Xanthotoxol is a hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been show n to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent stud ies show that it may also have antioxidant and anticancer activities.
Uses
A hydroxylated psoralen that inhibits neutrophil infiltration and brain edema induced by focal cerebral ischemia-reperfusion injury in rats. A potentially useful antiarrhythmic agent. It has been shown to be effective in the prevention of ventricular fibrillation of mice induced by chloroform, of rats induced by calcium chloride, and in treatment of rat arrhythmia induced by aconitine. Recent studies show that it may also have antioxidant and anticancer activities.
Definition
ChEBI: Xanthotoxol is an 8-hydroxyfurocoumarin.
Synthesis Reference(s)
Synthetic Communications, 37, p. 361, 2007 DOI: 10.1080/00397910601038616
XANTHOTOXOL Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3269 | 58 |
View Lastest Price from XANTHOTOXOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Xanthotoxol
2009-24-7
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2021-10-30 | XANTHOTOXOL
2009-24-7
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-04-28 | Xanthotoxol
2009-24-7
|
US $0.01-1.00 / KG | 1KG | 99% | 50 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Xanthotoxol
2009-24-7
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- XANTHOTOXOL
2009-24-7
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- Xanthotoxol
2009-24-7
- US $0.01-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd