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Nifedipine

Nifedipine Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: CAS:21829-25-4
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
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Products Intro: Product Name:Nifedipine
CAS:21829-25-4
Purity:99% Package:164/KG
Company Name: Shanghai EFE Biological Technology Co., Ltd.  Gold
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Products Intro:Product Name:Nifedipine ()
CAS:21829-25-4
Purity:0.98 Package:5mg;10mg;25mg;50mg;100MG
Company Name: Wuhan Hezhong Bio-chemical Manufacture co ltd  Gold
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Products Intro:Product Name:Nifedipine
CAS:21829-25-4
Purity:99% HPLC Package:100G;500G;1KG;25KG
Company Name: Taian Jiaye Biotechnology Co.Ltd  Gold
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Products Intro:Product Name: Nifedipine
CAS:1829-25-4
Purity:99% Package:135.00RMB/1KG
Nifedipine Basic information
Pharmacological effects Chemical properties Uses Production methods Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent
Product Name:Nifedipine
Synonyms:1,4-Dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl;Nifedipine,1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester;Nifedipine (125 mg);Niter benzene horizontal;1,4-dihydro-2,6-diMethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate;Nifidepine;Nifedipine, Micronized, USP;3,5-diMethyl 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS:21829-25-4
MF:C17H18N2O6
MW:346.34
EINECS:244-598-3
Product Categories:Ion Channels;Dihydropyridine;Pharmaceutical intermediate;Isotopically Labeled Pharmaceutical Reference Standard;CAPOTEN;Cardiovascular APIs;Cardiovascular Drugs;Pharmaceutical;Active Pharmaceutical Ingredients;Dihydropyridine Class Chemicals;Functional Materials;Photopolymerization Initiators;Intermediates & Fine Chemicals;Pharmaceuticals;Calcium channel
Mol File:21829-25-4.mol
Nifedipine Structure
Nifedipine Chemical Properties
Melting point 171-175 °C
storage temp. 2-8°C
solubility DMSO: soluble
form powder
color yellow
Water Solubility <0.1 g/100 mL at 19.5 ºC
Merck 14,6528
CAS DataBase Reference21829-25-4(CAS DataBase Reference)
NIST Chemistry ReferenceNifedipine(21829-25-4)
EPA Substance Registry System3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-( 2-nitrophenyl)-, dimethyl ester(21829-25-4)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 1
RTECS US7975000
HazardClass IRRITANT
MSDS Information
ProviderLanguage
Nifedipine English
SigmaAldrich English
ACROS English
Nifedipine Usage And Synthesis
Pharmacological effectsNifedipine is a kind of dihydropyridine calcium antagonists, it can inhibit the Ca2 + uptake of cardiac and vascular smooth muscles, and it can expand the coronary artery , increase coronary blood flow,and improve myocardial ischemic tolerance, at the same time, it can expand peripheral arteries and reduce peripheral vascular resistance,and relieve coronary artery spasm, and increase coronary blood flow, improve myocardial ischemia,in order to decrease the blood pressure. Small doses do not affect blood pressure, when expanding coronary artery ,it is a better anti-angina drug .It is used for the prevention and treatment of angina pectoris,with no adverse effects on respiratory function, its efficacy is best particularly for angina pectoris coronary spasm and obstructive airway disease with angina , its efficacy is superior to β-blockers.It is also applied to all types of high blood pressure, including severe and resistant hypertension. Treatment of refractory congestive heart failure may be taking this long. It is also used for the treatment of primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcers, urinary tract obstruction, exercise-induced asthma, achalasia.
Nifedipine has a certain selectivity on vascular smooth muscles , the direct negative inotropic effect and denaturation effect on the heart are weak, systemic administration of it does not cause the heart rate slowing down ,on the contrary, the heart rate performances reflected increase.
The above information is edited by the chemicalbook of Tian Ye.
Chemical propertiesYellow crystals. Melting point 172-174 ℃. Soluble in acetone, chloroform, ethyl acetate, dissolved in hot methanol, insoluble in water. It easily deteriorates in case of light.
UsesLong-term coronary vasodilators. This product can increase coronary blood flow, reducing myocardial oxygen consumption.it is used for acute and chronic coronary insufficiency,especially the angina and myocardial infarction.
Production methodsO-nitrobenzaldehyde, methyl acetoacetate, methanol, ammonia are refluxed together , then froze , crystallize,after filtration, nifedipine crude is obtained . The crude product is recrystallized through methanol .then the product is derived , yield rate is 50%.
CategoryToxic substances
Toxicity gradingHighly toxic
Acute toxicityOral-rat LD50: 1022 mg/kg; Oral-Mouse LD50: 310 mg/kg.
Flammability and hazard characteristicsCombustion produces toxic fumes of nitrogen oxides; medicinal side effects: low blood pressure, cardiac disease, local blood flow disease, high blood sugar, psychosis.
Storage CharacteristicsVentilated , low-temperature, drying; and it is kept separately from food raw materials warehouse.
Extinguishing agentDry powder, foam, sand, carbon dioxide, water spray.
Chemical PropertiesYellow Crystalline Solid
UsesUsed as an antihypertensive and antianginal. A dihydorpyridine calcium channel blocker
UsesFor the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).
General DescriptionOdorless yellow crystals or powder. Tasteless.
Air & Water ReactionsAqueous solutions are very sensitive to light. . Insoluble in water.
Reactivity ProfileNifedipine is sensitive to light.
Fire HazardFlash point data for Nifedipine are not available; however, Nifedipine is probably combustible.
Biological ActivityL-type calcium channel blocker.
Nifedipine Preparation Products And Raw materials
Raw materialsEthyl cyanoacetate-->Diethyl oxalate-->Benzaldehyde-->2-Nitrotoluene-->Methyl acetoacetate-->2-Nitrobenzaldehyde-->4-Aminobenzaldehyde
Tag:Nifedipine(21829-25-4) Related Product Information
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