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[General Description]
A light red or amber-colored liquid or crystals. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation or skin absorption. Used to make other chemicals. |
[Reactivity Profile]
NITROANISOLE(100-17-4) reacts explosively with (sodium hydroxide + zinc). NITROANISOLE(100-17-4) reacts vigorously with hydrogen + catalyst (at 482° F and 25500 mm Hg). |
[Air & Water Reactions]
Insoluble in water. |
[Health Hazard]
Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. |
[Fire Hazard]
Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. |
[Chemical Properties]
beige crystalline solid |
[Uses]
4-Nitroanisole is an intermediate in the manufacture of azo dyes. A toxic organic pollutant and a risk factor for urinary bladder cancer in humans. |
[Uses]
o-Isomer as dye intermediate; in organic syntheses. |
[Definition]
ChEBI: A member of the class of 4-nitroanisoles that is anisole in which one the hydrogen meta to the methoxy group is replaced by a nitro group. |
[Preparation]
Produced from p-nitrochlorobenzene by methoxylation. |
[Synthesis Reference(s)]
Synthetic Communications, 25, p. 1367, 1995 DOI: 10.1080/00397919508013838
Tetrahedron Letters, 14, p. 1397, 1973 |
[Biochem/physiol Actions]
4-Nitroanisole is O-demethylated to 4-nitrophenol by human liver microsomes. |
[Purification Methods]
Crystallise it from pet ether or hexane and dry it in vacuo. [Beilstein 6 IV 1282.] |