105-16-8

80-62-6

100-37-8

105-16-8

(1) Synthesis step: In a 1000 mL three-necked flask equipped with a stirrer, a thermometer and a moisture separator, 240 g (2.4 mol) of methyl methacrylate, 117 g (1.0 mol) of diethylaminoethanol, 200 g of n-hexane, 8 g of lithium hydroxide, and 0.5 g of phenothiazine were added sequentially. The reaction mixture was heated to 65 °C to 73 °C and kept at reflux to separate the resulting methanol. The reaction was continued until no methanol was separated (about 5 hours) and a total of 34.5 g of methanol was collected. The content of methanol was 88.6% and the content of methyl methacrylate was 11.2% by gas chromatography. (2) Purification step: After the reaction mixture was cooled to room temperature, it was washed twice with 300 mL×2 deionized water. Subsequently, the pressure was gradually reduced (0 to 100 mmHg) at 60 °C to 100 °C to remove unreacted methyl methacrylate and diethylaminoethanol. Finally, diethylaminoethyl methacrylate was obtained by distillation at 5 to 10 mmHg and 90 °C to 100 °C under reduced pressure. The product 175.7 g (theoretical yield 185.26 g) was obtained in 94.1% yield. Gas chromatographic analysis showed that the content of diethylaminoethyl methacrylate in the product was 99.2%.