| Identification | More | [Name]
2-Amino-5-methyl-1,3,4-thiadiazole | [CAS]
108-33-8 | [Synonyms]
2-AMINO-5-METHYL-1,3,4-THIADIAZOLE
2-AMINO-5-METHYLTHIADIAZOLE
5-METHYL-1,3,4-THIADIAZOL-2-AMINE
5-METHYL-[1,3,4]THIADIAZOL-2-YLAMINE
AKOS BBS-00007966
TIMTEC-BB SBB000045
TOSLAB 27625
VITAS-BB TBB000116
4-thiadiazol-2-amine,5-methyl-3
4-thiadiazole,2-amino-5-methyl-3
5-methyl-1,3,4-thiadiazole-2-amine
usafcy-3
1,3,4-Thiadiazole, 2-amino-5-methyl.
5-methyl-2-amino-1,3,4-thiadiazole
2-AMINO-5-METHYL-1,3,4-THIADIAZOLE 97%
2-AMINO-5-METHYL-1,3,4-THIADIZOLE
1,3,4-Thiadiazol-2-amine, 5-methyl | [EINECS(EC#)]
203-573-7 | [Molecular Formula]
C3H5N3S | [MDL Number]
MFCD00003110 | [Molecular Weight]
115.16 | [MOL File]
108-33-8.mol |
| Chemical Properties | Back Directory | [Appearance]
White to light beige crystalline powder | [Melting point ]
223-228 °C | [Boiling point ]
261.2±23.0 °C(Predicted) | [density ]
1.287 (estimate) | [refractive index ]
1.5800 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Sparingly), Methanol (Slightly) | [form ]
solid | [pka]
3.84±0.10(Predicted) | [color ]
Off-White | [InChI]
InChI=1S/C3H5N3S/c1-2-5-6-3(4)7-2/h1H3,(H2,4,6) | [InChIKey]
HMPUHXCGUHDVBI-UHFFFAOYSA-N | [SMILES]
S1C(C)=NN=C1N | [CAS DataBase Reference]
108-33-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3 | [RTECS ]
XI3500000 | [Hazard Note ]
Irritant | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
White to light beige crystalline powder | [Uses]
2-Amino-5-methyl-1,3,4-thiadiazole was used as a reagent in the synthesis of substituted 5H-benzo[i][1,3,4]thiadiazolo[3,2-a]quinazoline-6,7-diones which diplayed good cytotoxic activities. Also used in the design of new phenothiazine-thiadiazole hybrids for development of antitubercular agents. | [Definition]
ChEBI: 5-Methyl-1,3,4-thiadiazol-2-amine is a member of thiadiazoles. | [Synthesis]
1) 0.05 mol of aminothiourea was added to a dry mortar, followed by 0.055 mol of glacial acetic acid, 0.055 mol of silica, and 0.25 mol of phosphorus trichloride, and ground for 10 min at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC) using a solvent mixture of ethyl acetate and petroleum ether in the ratio of 1:3 by volume as the unfolding agent until the point of raw material aminothiourea disappeared, indicating that the reaction was complete. The crude product was obtained after standing for 30 min.2) The crude product was transferred to a beaker and the pH was adjusted to 8 by adding 5% sodium carbonate solution.The mixture was withdrawn and filtered and the filter cake was dissolved with N,N-dimethylformamide (DMF) to remove silica gel. The filtrate was concentrated under reduced pressure, and after removing the solvent, washed with water and filtered by suction to afford 2-amino-5-methyl-1,3,4-thiadiazole in 95.2% yield. | [References]
[1] Patent: CN103880776, 2016, B. Location in patent: Paragraph 0024-0026
[2] Bulletin of the Chemical Society of Japan, 1982, vol. 55, # 2, p. 637 - 638
[3] Synthetic Communications, 2000, vol. 30, # 16, p. 3031 - 3040
[4] Journal of the Chemical Society of Pakistan, 2015, vol. 37, # 1, p. 115 - 121
[5] Journal of Chemical Research, 2005, # 5, p. 341 - 343 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)MS
2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)1HNMR
2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)13CNMR
2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)IR1
2-Amino-5-methyl-1,3,4-thiadiazole(108-33-8)IR2
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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