| Identification | More | [Name]
1,4-BIS(2-HYDROXYETHYL)PIPERAZINE | [CAS]
122-96-3 | [Synonyms]
1,4'-BIS(2-HYDROXYETHYL)PIPERAZINE
1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
1,4-PIPERAZINEDIETHANOL
2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHANOL
AKOS BB-4936
DI(HYDROXYETHYL)PIPERAZINE
N,N'-BIS(2-HYDROXYETHYL)PIPERAZINE
N,N'-PIPERAZINDIETHANOL
N,N'-PIPERAZINEDIETHANOL
1,4-Bis(beta-hydroxyethyl)piperazine
1,4-Di(2-hydroxyethyl)piperazine
n,n’-bis(2-hydroxyethyl)-piperazin
n,n’-bis(beta-hydroxyethyl)piperazine
n,n’-di(2-hydroxyethyl)piperazine
N,N'-Bis(beta-hydroxyethyl)piperazine
N,N'-Di(2-hydroxyethyl)piperazine
N,N'-Dihydroxyethylpiperazine
Piperazine, N,N'-bis(2-hydroxyethyl)-
piperazine,N,N’-bis(2-hydroxyethyl)-
piperazine-1,4-diethanol | [EINECS(EC#)]
204-586-0 | [Molecular Formula]
C8H18N2O2 | [MDL Number]
MFCD00006157 | [Molecular Weight]
174.24 | [MOL File]
122-96-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
133.5-136 °C(lit.)
| [Boiling point ]
215-220 °C50 mm Hg(lit.)
| [density ]
1.097 | [vapor pressure ]
0.004Pa at 20℃ | [refractive index ]
1.4540 (estimate) | [Fp ]
166℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
powder to crystal | [pka]
14.66±0.10(Predicted) | [color ]
White to Almost white | [Water Solubility ]
Soluble in water. | [InChI]
1S/C8H18N2O2/c11-7-5-9-1-2-10(4-3-9)6-8-12/h11-12H,1-8H2 | [InChIKey]
VARKIGWTYBUWNT-UHFFFAOYSA-N | [SMILES]
OCCN1CCN(CCO)CC1 | [LogP]
-1.92 at 20℃ | [CAS DataBase Reference]
122-96-3(CAS DataBase Reference) | [EPA Substance Registry System]
1,4-Piperazinediethanol (122-96-3) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
TL3675000
| [TSCA ]
Yes | [HS Code ]
2933.59.9500 | [REACH Registrations]
Active | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1 |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Uses]
1,4-Piperazinediethanol is useful in the synthesis of salt-inducible kinase inhibitors for the treatment of diseases. | [Flammability and Explosibility]
Notclassified | [Synthesis]
The general procedure for the synthesis of N,N'-bis(2-hydroxyethyl)piperazine from diethanolamine is as follows:
Example 2: Preparation of 1,4-bis(hydroxyethyl)piperazine from diethanolamine under solvent-free conditions
Operational steps:
1. 100 g of diethanolamine (II) and 10 g of Catalyst A were added in the same reaction setup described in Example 1 .
2. Upon completion of the reaction, the reaction product was detected by gas chromatography analysis (GC column: 30m RTX Amin).
3. The analytical results showed that the content of 1,4-bis(hydroxyethyl)piperazine in the reaction product was 79% under the condition of complete conversion of diethanolamine. | [References]
[1] Patent: US2012/108816, 2012, A1. Location in patent: Page/Page column 6
[2] Patent: US2868791, 1954,
[3] Patent: US2636033, 1950,
[4] Patent: DE917784, 1952,
[5] Patent: DE917784, 1952, |
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