| Identification | Back Directory | [Name]
Bis-Propargyl-PEG4 | [CAS]
126422-58-0 | [Synonyms]
Bis-Propargyl-PEG4
Alkyne-PEG4-Alkyne
PROPARGYL-PEG4-PROPARGYL
4,7,10,13-Tetraoxahexadeca-1,15-diyne
α,ω-bis(O-propargyl)triethylene glycol | [Molecular Formula]
C12H18O4 | [MDL Number]
MFCD22683298 | [MOL File]
126422-58-0.mol | [Molecular Weight]
226.27 |
| Hazard Information | Back Directory | [Description]
Bis-propargyl-PEG4 enables Click Chemistry reactions with azide compounds via copper catalyzed azide-alkyne Click Chemistry. The PEG units enhance the solubility of the molecule in aqueous media. | [Uses]
Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity[1] [2]. Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Pearlie BURNETTE, et al. Dimeric immuno-modulatory compounds against cereblon-based mechanisms. WO2020014489A2.
[2] Rice DR, et al. Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes. Bioorg Med Chem. 2017 May 15;25(10):2754-2760. DOI:10.1016/j.bmc.2017.03.050 |
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