| Identification | Back Directory | [Name]
Diethylene Glycol Bis(2-propynyl) Ether | [CAS]
126422-57-9 | [Synonyms]
Bis-propargyl-PEG2
Bis-propargyl-PEG3
Alkyne-PEG3-Alkyne
PROPARGYL-PEG3-PROPARGYL
4,7,10-Trioxa-1,12-tridecadiyne
4,7,10-trioxahexadeca-1,12-diyne
α,ω-bis(O-propargyl)diethylene glycol
Diethylene Glycol Bis(2-propynyl) Ether
Diethylene Glycol Bis(2-propynyl) Ether >
1-Propyne, 3,3'-[oxybis(2,1-ethanediyloxy)]bis-
3-[2-[2-(2-Propynyloxy)ethoxy]ethoxy]-1-propyne
3-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)prop-1-yne | [Molecular Formula]
C10H14O3 | [MDL Number]
MFCD03640302 | [MOL File]
126422-57-9.mol | [Molecular Weight]
182.216 |
| Chemical Properties | Back Directory | [Boiling point ]
103°C/6mmHg(lit.) | [density ]
1.011±0.06 g/cm3(Predicted) | [refractive index ]
1.4610 to 1.4650 | [form ]
clear liquid | [color ]
Colorless to Light yellow |
| Hazard Information | Back Directory | [Description]
Bis-propargyl-PEG3 is a crosslinker with alkyne groups at both ends of the molecule. The alkyne groups react with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry to form a stable triazole linkage. | [Uses]
Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers[1][2]. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Shenoi RA, et al. Synthesis, characterization, and biocompatibility of biodegradable hyperbranched polyglycerols from acid-cleavable ketal group functionalized initiators. Biomacromolecules. 2012 Oct 8;13(10):3018-30. DOI:10.1021/bm300959h
[2] Jiang, et al. Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis. Tetrahedron, 2018: 74(27), 3527–3533. |
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