| Identification | Back Directory | [Name]
1-Boc-azetidine-3-ylmethanol | [CAS]
142253-56-3 | [Synonyms]
EOS-61767
Boc-Azetidin-3-ylMethanol
1-Boc-3-(hydroxymethyl)az...
1-Boc-3-azetidinemethanol,95%
1-BOC-AZETIDINE-3-YL METHANOL
1-Boc-3-azetidineMethanol, 95%
1-N-Boc-3-hydroxyMethyazetidine
1-Boc-3-(hydroxymethyl)azetidine
1-Boc-3-(hydroxyMethyl)azetidine, 97+%
3-(Hydroxymethyl)azetidine-1-carboxylate
1-(tert-Butoxycarbonyl)-3-azetidineMethanol
tert-butyl 2-(azetidin-3-yl)-2-hydroxyacetate
1-(tert-Butoxycarbonyl)-3-azetidinemethanol >
TERT-BUTYL 3-(HYDROXYMETHYL)AZETIDINE-1-CARBOXYLATE
3-HYDROXYMETHYL-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
1-Azetidinecarboxylic acid, 3-(hydroxyMethyl)-, 1,1-diMethylethyl ester | [EINECS(EC#)]
218-697-7 | [Molecular Formula]
C9H17NO3 | [MDL Number]
MFCD06656141 | [MOL File]
142253-56-3.mol | [Molecular Weight]
187.24 |
| Questions And Answer | Back Directory | [Synthesis]
Starting with valerolactone, methyl 2,5-dibromovalerate is obtained through bromination and ring-opening. This methyl 2,5-dibromovalerate is then disubstituted and cyclized with α-phenylethylamine to generate aza-1-[(S)-1-phenethyl]-3-methoxycarbonylazacyclobutane. After column chromatography separation, reduction to an alcohol by lithium aluminum hydride, followed by hydrogenolysis to remove the 1-phenethyl group and introduce a Boc protecting group, yielding 1-Boc-Azetidine-3-yl-methanol. The synthetic reaction formula is shown in the figure below:
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| Chemical Properties | Back Directory | [Melting point ]
55 °C | [Boiling point ]
268-273℃ | [density ]
1.115 | [Fp ]
117°(243°F) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in Dimethyl sulfoxide (DMSO). | [form ]
powder to lump | [pka]
14.82±0.10(Predicted) | [color ]
White to Almost white | [InChI]
InChI=1S/C9H17NO3/c1-9(2,3)13-8(12)10-4-7(5-10)6-11/h7,11H,4-6H2,1-3H3 | [InChIKey]
HXRDRJKAEYHOBB-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CC(CO)C1 |
| Hazard Information | Back Directory | [Description]
1-Boc-Azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). This compound is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
| [Chemical Properties]
Clear colorless liquid | [Uses]
It is an intermediate in organic syntheses |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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