| Identification | More | [Name]
(R)-(+)-Propylene carbonate | [CAS]
16606-55-6 | [Synonyms]
(R)-1,2-PROPANEDIOL CARBONATE
(R)-(+)-1,2-PROPYLENE CARBONATE
(R)-1,2-PROPYLENE CARBONATE
(R)-(+)-4-METHYL-1,3-DIOXOLAN-2-ONE
(R)-4-METHYL-1,3-DIOXOLAN-2-ONE
(R)-(+)-PROPYLENE CARBONATE
(R)-PROPYLENE CARBONATE
(R)-Propandiolcarbonate
R-5-Methoxymethyl-2-oxazolidinone
(R)-(+)-PROPYLENE CARBONATE, 98% (98% EE
(R-(+-PropyleneCarbonate))-IntermediateForTenofovir
(r)-1,2-propanediol cyclic carbonate
(4R)-4-Methyl-1,3-dioxolan-2-one
(R)-1,2-Propanediol cyclic carbonate, (R)-(+)-Propylene carbonate
(R)-Propylene carbonate (R)-1,2-Propanediol carbonate
(R)-(+)-PROPYLENE CARBONATE, 98% E.E. 98% ASSAY
1,3-Dioxolan-2-one,4-methyl-,(4R)-
(R)-5-Methyl-1,3-dioxolan-2-one
Carbonic acid (R)-propylene ester | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C4H6O3 | [MDL Number]
MFCD00798265 | [Molecular Weight]
102.09 | [MOL File]
16606-55-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Boiling point ]
240 °C(lit.)
| [density ]
1.189 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.59 psi ( 20 °C)
| [refractive index ]
n20/D 1.422(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Sparingly) | [form ]
Oil | [color ]
Clear Colourless to Pale Yellow | [Specific Gravity]
1.189 | [Optical Rotation]
[α]20/D +2°, neat | [Water Solubility ]
175 g/L (25 ºC) | [InChI]
InChI=1S/C4H6O3/c1-3-2-6-4(5)7-3/h3H,2H2,1H3/t3-/m1/s1 | [InChIKey]
RUOJZAUFBMNUDX-GSVOUGTGSA-N | [SMILES]
O1C[C@@H](C)OC1=O | [CAS DataBase Reference]
16606-55-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
FF9650000 | [REACH Registrations]
Inactive | [HS Code ]
29329990 |
| Hazard Information | Back Directory | [Description]
(R)-(+)-Propylene carbonate, also known as (R)-1,2-Propanediol cyclic carbonate, presents as a colorless to pale yellow liquid. This compound should keep the container tightly closed and stored in a cool and dark place. For best results, store under inert gas, protected from moisture, as this substance is moisture-sensitive. (R)-(+)-Propylene carbonate is incompatible with oxidizing agents and acids. This chemical causes skin irritation as well as serious eye irritation.
| [Chemical Properties]
Colorless to light yellow liqui | [Uses]
(R)-1,2-Propylene Carbonate (cas# 16606-55-6) is a compound useful in organic synthesis. | [Synthesis]
The general procedure for the synthesis of R-propylene carbonate from (R)-1,2-propanediol and diethyl carbonate was as follows: (R)-1,2-propanediol (38.05 kg, 500 mol) was added to a glass-lined reactor, followed by the addition of diethyl carbonate (70.88 kg, 600 mol) and sodium ethoxide (3.4 kg, 50 mol). The reaction mixture was heated to 105-110 °C and maintained for 8 hours. After completion of the reaction, unreacted diethyl carbonate was removed by distillation under reduced pressure. After the reaction mixture was cooled to room temperature, the insoluble material was removed by filtration. Finally, the solvent was removed by evaporation of the filtrate to afford R-propylene carbonate (34.24 kg, purity ≥99%) in 90% yield. | [References]
[1] Patent: CN105859781, 2016, A. Location in patent: Paragraph 0011-0012
[2] Patent: US2010/216822, 2010, A1. Location in patent: Page/Page column 13
[3] Tetrahedron Letters, 1998, vol. 39, # 14, p. 1853 - 1856
[4] Patent: EP1243590, 2002, A2. Location in patent: Page 9
[5] Patent: CN102977146, 2016, B. Location in patent: Paragraph 0016; 0021; 0023 |
|
| Company Name: |
Changzhou Huaren Chemical Co., Ltd Gold
|
| Telephone: |
0519-88103998, 13646148298, 88103997, 88122965,88100916 13646148298;051988100916; |
| Website: |
http://www.huarenchem.com |
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|