| Identification | More | [Name]
3-Hydroxyazetidine hydrochloride | [CAS]
18621-18-6 | [Synonyms]
3-AZETIDINOL HYDROCHLORIDE
3-HYDROXYAZETIDINE HCL
3-HYDROXYAZETIDINE HYDROCHLORIDE
AZETIDIN-3-OL HYDROCHLORIDE
AZETIDIN-3-OL, HYDROCHLORIDE SALT
BUTTPARK 75\04-67
AZETAN-2-ONE | [EINECS(EC#)]
628-004-3 | [Molecular Formula]
C3H8ClNO | [MDL Number]
MFCD02683887 | [Molecular Weight]
109.55 | [MOL File]
18621-18-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystal | [Melting point ]
85-90 °C | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
Soluble in water, DMSO, methanol. | [Sensitive ]
Hygroscopic | [Usage]
A useful intermediate in the synthesis of polypeptides | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H | [InChIKey]
UQUPQEUNHVVNKW-UHFFFAOYSA-N | [SMILES]
C1(O)CNC1.Cl | [CAS DataBase Reference]
18621-18-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H302-H315-H318-H335 | [Precautionary statements ]
P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | [Hazard Codes ]
C,Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R41:Risk of serious damage to eyes.
R37/38:Irritating to respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN1759 | [WGK Germany ]
3 | [Hazard Note ]
Harmful/Corrosive | [REACH Registrations]
Active | [HazardClass ]
IRRITANT | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis. | [Chemical Properties]
white crystal | [Uses]
3-Hydroxyazetidine hydrochloride is a useful intermediate in the synthesis of polypeptides.
| [Synthesis]
A solution of l-(diphenylmethyl)-3-hydroxy azetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker (4 atm). After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94%).
 | [IC 50]
Non-cleavable Linker | [References]
[1] Journal of Antibiotics, 2006, vol. 59, # 4, p. 241 - 247
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4601 - 4608
[3] Patent: WO2007/118830, 2007, A1. Location in patent: Page/Page column 91
[4] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 57-58
[5] Patent: WO2006/21881, 2006, A2. Location in patent: Page/Page column 62; 63 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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