| Identification | More | [Name]
(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid | [CAS]
20445-31-2 | [Synonyms]
(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(+)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
(+)-MOSHER'S ACID
MOSHERS ACID
(+)-MTPA
(R)-(+)-1-METHOXY-1-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(R)-(+)-2-METHOXY-2-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(R)-(+)-ALPHA-METHOXY-ALPHA-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(R)-(+)-A-METHOXY-A-(TRIFLUOROMETHYL)PHENYLACETIC ACID
(R)-(+)-MOSHER'S ACID
(R)-(+)-MPTA
(R)-(+)-α-Methoxy-α-trifluoromethylphenylacetic acid
(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylaceticacid(ee)
(R)-(+)-MTPA,(R)-(+)-Mosher'sacid
(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%(e.e.>99.5%)
(+)--Methoxy--(trifluoromethyl)phenylaceticacid(Moshersacid)
(r)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetic acid
(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid 99% (99%ee)
(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid (99%ee)
(R)-(+)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetic acid, 99% | [EINECS(EC#)]
243-829-5 | [Molecular Formula]
C10H9F3O3 | [MDL Number]
MFCD00004184 | [Molecular Weight]
234.17 | [MOL File]
20445-31-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline low melting solid | [Melting point ]
46-49 °C(lit.) | [alpha ]
D25 +68.5 ± 1.3° (c = 1.49 in CH3OH) | [Boiling point ]
105-107 °C1 mm Hg(lit.) | [density ]
1.344 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.473(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
Soluble in methanol (50 mg/ 1 ml). | [form ]
Crystalline Low Melting Solid | [pka]
1.47±0.10(Predicted) | [color ]
White | [Specific Gravity]
1.344 | [Optical Rotation]
[α]20/D +73±1°, c = 2% in methanol | [Sensitive ]
Hygroscopic | [Merck ]
14,6280 | [BRN ]
2215440 | [InChI]
1S/C10H9F3O3/c1-16-9(8(14)15,10(11,12)13)7-5-3-2-4-6-7/h2-6H,1H3,(H,14,15)/t9-/m1/s1 | [InChIKey]
JJYKJUXBWFATTE-SECBINFHSA-N | [SMILES]
CO[C@@](C(O)=O)(c1ccccc1)C(F)(F)F | [CAS DataBase Reference]
20445-31-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
3-10 | [Hazard Note ]
Irritant/Keep Cold | [HazardClass ]
IRRITANT, HYGROSCOPIC, KEEP COLD | [HS Code ]
29189900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline low melting solid | [Uses]
(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR. | [Uses]
Mosher′s acid chloride is used as a dervatization agent for β-arylethylamines, enantiomeric alcohols, and enantiomeric amines. It is also a reagent used for the determination of enantiomeric purity and absolute configuration of alcohols and amines by NMR. | [General Description]
Mosher′s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines. | [Purification Methods]
A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.] |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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