| Identification | More | [Name]
(R)-(-)-alpha-Methoxyphenylacetic acid | [CAS]
3966-32-3 | [Synonyms]
O-METHYL-D-MANDELIC ACID
(R)-(-)-ALPHA-METHOXYPHENYLACETIC ACID
(R)-ALPHA-METHOXYPHENYLACETIC ACID
(R)-(-)-A-METHOXYPHENYLACETIC ACID
(R)-(-)-METHOXYPHENYLACETIC ACID
Benzeneacetic acid, alpha-methoxy-, (R)-
R-MINUS-A-METHOXYPHENYL ACETIC ACID
O-Methyl-(R)-mandelicacid
(r)-(-)-à-methoxyphenylacetic acid
(R)-(-)-ALPHA-METHOXYPHENYLACETIC ACID 99%
(R)-(-)-ɑ-Methoxyphenylacetic acid, 99%
(2R)-2-Methoxy-2-phenylacetic acid
(R)-α-Methoxybenzeneacetic acid
(αR)-α-Methoxybenzeneacetic acid
[R,(-)]-α-Methoxybenzeneacetic acid | [EINECS(EC#)]
223-580-9 | [Molecular Formula]
C9H10O3 | [MDL Number]
MFCD00004250 | [Molecular Weight]
166.17 | [MOL File]
3966-32-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white fine crystalline powder or needles | [Melting point ]
66-68 °C(lit.)
| [alpha ]
-160.4 º (C=1, MEOH) | [Boiling point ]
164-166°C 18mm | [density ]
1.1708 (rough estimate) | [refractive index ]
-147 ° (C=0.5, EtOH) | [Fp ]
164-166°C/18mm | [storage temp. ]
2-8°C
| [solubility ]
Chloroform, Ethanol, Methanol | [form ]
Fine Crystalline Powder or Needles | [pka]
3.10±0.10(Predicted) | [color ]
White | [Optical Rotation]
[α]20/D -150±3°, c = 0.5% in ethanol | [BRN ]
3589257 | [CAS DataBase Reference]
3966-32-3(CAS DataBase Reference) | [NIST Chemistry Reference]
(R)-(-)-«alpha»-methoxyphenylacetic acid(3966-32-3) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29189900 |
| Hazard Information | Back Directory | [Chemical Properties]
white fine crystalline powder or needles | [Uses]
(R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors. | [General Description]
(R)-(?)-α-Methoxyphenylacetic acid is a chiral derivatizating agent, which is employed for derivatizing enantiomers into diastereoisomers. | [Purification Methods]
Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.] |
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