| Identification | More | [Name]
2-Amino-4-hydroxy-1H-pteridine | [CAS]
2236-60-4 | [Synonyms]
2-AMINO-4-HYDROXY-1H-PTERIDINE
2-AMINO-4-HYDROXYPTERIDINE
2-AMINO-4-OXODIHYDROPTERIDINE
2-AMINO-4-PTERIDINOL
PTERIN
PTERINE
2-amino-4(1h)-pteridinon
2-amino-4(1h)-pteridinone
4-oxopterin
pteridoxamine
2-amino-1H-pteridin-4-one
2-Amino-4-oxy-3,4-dihydropteridine
2-amino-4-hydroxyaminopteridine
4(1H)-Pteridinone,2-amino-
2-AMINO-4-HYDROXYPTERIDINE 98%
2-Amino-4-hydroxypteridine, 2-Amino-4-oxodihydropteridine
2-Aminopteridin-4(1H)-one
2-Aminopteridin-4-ol
Pterin【keto form】 | [EINECS(EC#)]
218-799-1 | [Molecular Formula]
C6H7N5O | [MDL Number]
MFCD00010557 | [Molecular Weight]
165.15 | [MOL File]
2236-60-4.mol |
| Chemical Properties | Back Directory | [Appearance]
YELLOW-BEIGE CRYSTALLINE POWDER | [Melting point ]
300 °C
| [Boiling point ]
290.2°C (rough estimate) | [density ]
1.4240 (rough estimate) | [refractive index ]
1.9000 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
Acetonitrile: Soluble
Water: Soluble | [form ]
powder | [pka]
2.27(at 20℃) | [biological source]
synthetic | [Water Solubility ]
17.54mg/L(22.5 ºC) | [BRN ]
150294 | [InChI]
InChI=1S/C6H5N5O/c7-6-10-4-3(5(12)11-6)8-1-2-9-4/h1-2H,(H3,7,9,10,11,12) | [InChIKey]
HNXQXTQTPAJEJL-UHFFFAOYSA-N | [SMILES]
N1C2C(=NC=CN=2)C(=O)NC=1N | [CAS DataBase Reference]
2236-60-4(CAS DataBase Reference) | [NIST Chemistry Reference]
4(1H)-pteridinone, 2-amino-(2236-60-4) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
UO3505000
| [F ]
10-23 | [HS Code ]
29335990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
YELLOW-BEIGE CRYSTALLINE POWDER | [Uses]
Pterin is used in the biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin. | [Definition]
ChEBI: 2-aminopteridin-4-ol is a 2-amino-4-hydroxypteridine. It is a tautomer of a 2-aminopteridin-4(3H)-one and a 2-aminopteridin-4(1H)-one. | [Biological Activity]
Pterine consists of pyrazine and pyrimidine with substitutions in keto and amino group. Pterine is present in all organisms including cyanobacteria. It acts as a cofactor for redox enzymes and serves as a precursor for folic acid synthesis. Pterine from the butterfly wings absorb light and elicit incoherent scattering. Pterine induces alterations in DNA by hydroxylation of deoxyguanosine. | [Purification Methods]
It is dissolved in hot 1% aqueous ammonia, filtered, and an equal volume of hot 1M aqueous formic acid is added. The solution is allowed to cool at 0-2o overnight. The solid is collected and washed with distilled water several times by centrifugation and dried in vacuo over P2O5 overnight, and then at 100o overnight (any ammonium formate in the sample evaporates off). [Beilstein 26 III/IV 3936.] | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] RAMASAMY MAHENDRAN. Evaluation of Pterin, a Promising Drug Candidate from Cyanide Degrading Bacteria.[J]. Current Microbiology, 2018, 75 6: 684-693. DOI: 10.1007/s00284-018-1433-0
[3] SANJEEWA GAMAGEDARA Yinfa M Stephen Gibbons. Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer[J]. Clinica Chimica Acta, 2011, 412 1: Pages 120-128. DOI: 10.1016/j.cca.2010.09.015 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
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https://www.jkchemical.com |
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