| Identification | More | [Name]
4-Amino-3-fluoropyridine | [CAS]
2247-88-3 | [Synonyms]
3-FLUORO-4-AMINOPYRIDINE
4-AMINO-3-FLUOROPYRIDINE
3-FLUOROPYRIDIN-4-AMINE
4-AMINO-3-FLUOROPYRINE
4-Amino-3-fluoropyridine
fluoropyridin-4-amine
3-Fluoro-4-pyridinamine
4-Amino-3-fluoropyridine ,98% | [Molecular Formula]
C5H5FN2 | [MDL Number]
MFCD00234072 | [Molecular Weight]
112.11 | [MOL File]
2247-88-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow to light yellow crystals | [Melting point ]
71-79 °C | [Boiling point ]
217.1±20.0 °C(Predicted) | [density ]
1.257±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
7.19±0.12(Predicted) | [color ]
White to Light yellow to Light orange | [Detection Methods]
HPLC | [InChI]
InChI=1S/C5H5FN2/c6-4-3-8-2-1-5(4)7/h1-3H,(H2,7,8) | [InChIKey]
UFIKBUVVVGSMGW-UHFFFAOYSA-N | [SMILES]
C1=NC=CC(N)=C1F | [CAS DataBase Reference]
2247-88-3(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Preparation]
In a 250 ml reaction flask, add 50 ml of water and 5.4 g of sodium hydroxide. Cool the reaction mixture to 0–5 °C. Add 4.7 g of liquid bromine dropwise to the reaction mixture. After the addition is complete, stir at 0–5 °C for 2 hours. Add 5.0 g of 3-fluoro-4-pyridinecarboxamide to the reaction flask. Stir at 0–5 °C for 2 hours until the solid is completely dissolved. Heat the reaction mixture to 85 °C. Maintain the reaction at 85 °C for 6 hours. Cool the reaction mixture to room temperature. Add 50 ml of ethyl acetate to the reaction flask to extract the product. Separate the organic layer and extract the aqueous layer twice with ethyl acetate. Combine the organic layers. 3.0 g of the pale brownish-red solid powder product, 4-amino-3-fluoropyridine, was obtained by drying and evaporating the solvent, with a yield of 81% and a purity of 96%. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H319 | [Precautionary statements ]
P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
nwg | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow to light yellow crystals | [Uses]
4-Amino-3-fluoropyridine is an important intermediate in the synthesis of many new drugs, and it is an intermediate in the synthesis of transforming growth factor-β inhibitors and thrombin inhibitors. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
|