| Identification | More | [Name]
2-Amino-5-fluoropyridine | [CAS]
21717-96-4 | [Synonyms]
5-FLUORO-2-AMINOPYRIDINE
5-FLUORO-2-PYRIDINAMINE
5-FLUOROPYRIDIN-2-AMINE
5-FLUORO-PYRIDIN-2-YL-AMINE
2-Amino-5-fluoroypyridine
2-Amino-5-fluoropyridine 95%
2-Amino-5-fluoropyridine95%
2-AMINO-5-FLUOROPYRIDINE, 98+%
2-AMINO-5-FLUOROPYRIDINE 5-FLUORO-PYRIDIN-2-YLAMINE
2-Amino-5-fluoropyridine ,97% | [EINECS(EC#)]
627-638-8 | [Molecular Formula]
C5H5FN2 | [MDL Number]
MFCD01861120 | [Molecular Weight]
112.11 | [MOL File]
21717-96-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow Cryst | [Melting point ]
93-97 °C (lit.) | [Boiling point ]
125 °C | [density ]
1.257±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
soluble in Methanol | [form ]
Powder | [pka]
4.62±0.13(Predicted) | [color ]
White to orange | [Detection Methods]
HPLC | [BRN ]
385938 | [InChI]
InChI=1S/C5H5FN2/c6-4-1-2-5(7)8-3-4/h1-3H,(H2,7,8) | [InChIKey]
YJTXQLYMECWULH-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=C(F)C=C1 | [CAS DataBase Reference]
21717-96-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN2811 | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [PackingGroup ]
II | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow Cryst | [Uses]
2-Amino-5-fluoropyridine is used in chemical microarrays to identify ligands that binds pathogenic cells. Acts as a reagent in the preparation of heterocyclic compounds as integrase inhibiting antiviral agents. | [Application]
2-Amino-5-fluoropyridine is a versatile fluorinated pyridine building block widely used to prepare peptide deformylase inhibitors such as the antibacterial agent LBM415, as well as herbicides, fungicides, and PET imaging probes; the combined electron-withdrawing fluorine and nucleophilic amino substituents enhance metabolic stability and bioavailability of the resulting active pharmaceutical or agrochemical ingredients. | [Definition]
ChEBI: 2-Amino-5-fluoropyridine is a dihydropyridine. | [Synthesis]
2-Amino-5-fluoropyridine is an important intermediate for the synthesis of LBM415 which is the peptide deformylas inhibitor. Using 2-aminopyridine as raw material and via nitrification, amino acetylation, reduction of nitro, diazolization, Schiemann reaction and hydrolysis of acetyl. | [References]
[1] E. S. HAND, D. C. BAKER. “ChemInform Abstract: Syntheses of 2-Chloro- and 2-Amino-5-fluoropyridines and Isolation of a Novel Difluoroboryl Imidate.” ChemInform 21 19 (1990).
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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