| Identification | More | [Name]
2,6-Dichloro-7-methylpurine | [CAS]
2273-93-0 | [Synonyms]
2,6-DICHLORO-7-METHYL-7H-PURINE
2,6-DICHLORO-7-METHYLPURINE
2,6-dichloro-7-methyl-purin
2,6-DICHLORO-7-METHYLPURINE 97% (HPLC) | [Molecular Formula]
C6H4Cl2N4 | [MDL Number]
MFCD00039690 | [Molecular Weight]
203.03 | [MOL File]
2273-93-0.mol |
| Hazard Information | Back Directory | [Uses]
2,6-DICHLORO-7-METHYLPURINE is used in the preparation and discover of novel mTOR INHIBITORS. | [Synthesis]
A reaction was carried out in acetonitrile (200 mL) in the presence of potassium carbonate (1.2 eq., 4.39 g) with 2,6-dichloropurine (5.0 g, 1.0 eq.) and iodomethane (1.1 eq., 1.81 mL). The reaction mixture was stirred at 20 °C for 70 hours. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was separated by column chromatography (eluent: dichloromethane/methanol, 90/10, v/v) to afford 2,6-dichloro-9-methyl-9H-purine (3.55 g, 66% yield) and 2,6-dichloro-7-methylpurine (1.61 g, 30% yield). | [References]
[1] Patent: WO2005/28479, 2005, A2. Location in patent: Page/Page column 58
[2] Patent: US2011/86841, 2011, A1. Location in patent: Page/Page column 25
[3] Patent: WO2016/115434, 2016, A1. Location in patent: Page/Page column 222; 223
[4] Patent: WO2010/34707, 2010, A1. Location in patent: Page/Page column 15
[5] Patent: US2011/251217, 2011, A1. Location in patent: Page/Page column 6-7 |
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