| Identification | More | [Name]
2,5-Dichloropyridine | [CAS]
16110-09-1 | [Synonyms]
2,5-DICHLOROPYRIDINE
2,5-dichloro-pyridin
4-Aminophenylacetamide
2,5-DICHLORPYRIDINE
2,5-Dichloropyridine97%
Dichloropyridine
2,5-DICHLOROPYRIDINE 2,5-DICHLOROPYRIDINE
Pyridine, 2,5-dichloro- | [EINECS(EC#)]
240-278-2 | [Molecular Formula]
C5H3Cl2N | [MDL Number]
MFCD00006239 | [Molecular Weight]
147.99 | [MOL File]
16110-09-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly yellow crystalline solid | [Melting point ]
59-62 °C (lit.) | [Boiling point ]
190-191 °C
| [density ]
1.5159 (rough estimate) | [refractive index ]
1.5500 (estimate) | [Fp ]
112 °C
| [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Crystalline Solid | [pka]
-2.25±0.10(Predicted) | [color ]
White to slightly yellow | [Water Solubility ]
insoluble | [BRN ]
108886 | [CAS DataBase Reference]
16110-09-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
UN2811 | [WGK Germany ]
3
| [RTECS ]
US8225000
| [Hazard Note ]
Harmful | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [HS Code ]
29333990 |
| Questions And Answer | Back Directory | [Uses]
2,5-Dichloropyridine is a reagent used in chemical synthesis. It has been used to synthesize 4-benzodiazepine-2,5 diones as Hdm2 antagonists and inhibitors of ERK protein kinase. |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Sulfuric acid-->Dichloromethane-->Sodium sulfate-->Sodium chloride-->3-Chloroperoxybenzoic acid-->Trimethylamine-->Benzenesulfonyl chloride-->3-Chloropyridine-->3-CHLOROPYRIDINE N-OXIDE-->3,4-Dichloropyridine-->2,3-Dichloropyridine | [Preparation Products]
2,5-DICHLORO-4-FORMYLPYRIDINE-->2,5-Dichloroisonicotinic acid-->2-Bromo-5-chloropyridine-->5-Chloropyridine-2-thiol-->5-CHLORO-3-METHYL-PYRIDINE-2-CARBOXYLIC ACID-->2,5-DICHLORO-3-IODOPYRIDINE-->2,5-Dichloro-4-iodopyridine-->5-Chloropyridine-2-carboxylic acid-->4-Piperidinol, 1-[6-(5'-chloro-3,5-dimethyl[2,4'-bipyridin]-2'-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl]- |
| Hazard Information | Back Directory | [Chemical Properties]
white to slightly yellow crystalline solid | [Synthesis Reference(s)]
Synthetic Communications, 20, p. 2971, 1990 DOI: 10.1080/00397919008051514 | [General Description]
2,5-Dichloropyridine undergoes cross-coupling reaction with arylboronic acids in the presence of [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride as catalyst. |
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