| Identification | More | [Name]
Cyclohexanecarboxylic acid chloride | [CAS]
2719-27-9 | [Synonyms]
AKOS BBS-00003918
CYCLOHEXANECARBONYL CHLORIDE
CYCLOHEXANECARBOXYLIC ACID CHLORIDE
HEXAHYDROBENZOYL CHLORIDE
Chlorocarbonylcyclohexane
Cyclohexanoyl chloride
Cyclohexylcarbonyl chloride
Cyclohexyl Carboxylic Acid Chloride
Cyclotexaformyl Chloride
Cyclohexanecarbonic acid chloride
Cyclohexanecarbonyl chloride (6CI,7CI,8CI,9CI)
Cyclohexanecarbonylchloride,98%
CYCLO HEXANE CARBOYL CHLORIDE
CYCLOHEXANECARBONY CHLORIDE
Cyclohexane carbonlchloride
Cyclohexancarbonylchlorid
Cyclohexane-1-carboxylic acid chloride | [EINECS(EC#)]
220-322-7 | [Molecular Formula]
C7H11ClO | [MDL Number]
MFCD00001456 | [Molecular Weight]
146.61 | [MOL File]
2719-27-9.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless to straw coloured liquid | [Boiling point ]
184 °C (lit.) | [density ]
1.096 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.469(lit.)
| [Fp ]
152 °F
| [storage temp. ]
Store below +30°C. | [form ]
Liquid | [color ]
Clear colorless to straw | [Specific Gravity]
1.096 | [Water Solubility ]
HYDROLYSES | [Sensitive ]
Moisture Sensitive | [BRN ]
742163 | [InChI]
1S/C7H11ClO/c8-7(9)6-4-2-1-3-5-6/h6H,1-5H2 | [InChIKey]
RVOJTCZRIKWHDX-UHFFFAOYSA-N | [SMILES]
ClC(=O)C1CCCCC1 | [CAS DataBase Reference]
2719-27-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Cyclohexanecarbonyl chloride(2719-27-9) | [EPA Substance Registry System]
2719-27-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H302-H314-H335 | [Precautionary statements ]
P261-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R37:Irritating to the respiratory system.
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
1
| [F ]
9-19-21 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29162000 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Corr. 1B
STOT SE 3 | [Toxicity]
LD50 orally in Rabbit: 965 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
clear colourless to straw coloured liquid | [Uses]
Cyclohexanecarbonyl chloride is used in the preparation of five thiourea derivative ligands having anti-bacterial and anti-yeast activity, (N-(diethylcarbamothioyl)cyclohexanecarboxamide, N-(di-n-propylcarbamothioyl)cyclohexanecarboxamide, di-n-butylcarbamothioyl)cyclohexanecarboxamide, N-(diphenylcarbamothioyl)cyclohexanecarboxamide, N-(morpholine-4-carbonothioyl)cyclohexanecarboxamide. | [General Description]
Electrochemical reduction of cyclohexanecarbonyl chloride at a hanging mercury drop electrode in acetonitrile has been reported. | [Synthesis]
The general procedure for the synthesis of cyclohexanecarboxylic acid from cyclohexanecarboxylic acid is as follows: 20.0 g (of which 6.95 g, 0.054 mol, of cyclohexanecarboxylic acid) of cyclohexanecarboxylic acid solution was added to 1.0 g of n-dodecane (as an internal standard) to a reactor fitted with a condenser and a Dean-Stark water separator. After adding 90 mL of benzene, about 25 mL of benzene was removed by distillation under nitrogen protection to prepare an anhydrous solution. After the reaction solution was cooled to room temperature, 6.0 mL (9.8 g, 0.082 mol) of thionyl chloride was added and the reaction was refluxed for 1 hour. After completion of the reaction, a portion of the reaction solution was taken and reacted with methanol containing a small amount of triethylamine, which was used to identify the product cyclohexanecarbonyl chloride. The yield of methyl cyclohexanecarboxylate was analyzed by gas chromatography (GC). The results showed that the conversion of cyclohexanecarboxylic acid chloride was more than 99% and the selectivity was higher than 99%. | [References]
[1] Patent: US2004/73068, 2004, A1. Location in patent: Page 3
[2] Patent: US2004/73068, 2004, A1. Location in patent: Page 4
[3] Patent: US2004/73068, 2004, A1. Location in patent: Page 3
[4] Canadian Journal of Chemistry, 1996, vol. 74, # 12, p. 2401 - 2412
[5] Organic Syntheses, 1983, vol. 61, p. 134 - 134 |
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