| Identification | More | [Name]
Thiophene-2-ethylamine | [CAS]
30433-91-1 | [Synonyms]
2-(2-AMINOETHYL)THIOPHENE
2-(2-THIENYL)-1-ETHANAMINE
2-(2-THIENYL)-1-ETHANAMINE HYDROCHLORIDE
2-(2'-THIENYL)ETHYL AMINE
2-(2-THIENYL)ETHYLAMINE
2-AMINOETHYLTHIOPHENE
2-THIOPHENEETHYLAMINE
B-2-THIENYLETHYLAMINE
RARECHEM AL BW 0099
THIOPHENE-2-ETHYLAMINE
THIOPHENE-2-ETHYLAMINE HCL SALT
THIOPHENE ETHYLAMINE
20(2-thienyl)ethylamine
2-(2'-Thienyl) ethyl amine/ Thiophene-2-ethylamine
2-(2-Aminoethyl)thiophene~Thiophene-2-ethylamine
2-Thiopheneethylamin
2-Thiophen-2-ylethanamine
Thiophene-2-Ethylamine ,99%
2-(2-Thienyl)ethanamine
2-Thiopheneethanamine | [EINECS(EC#)]
250-196-9 | [Molecular Formula]
C6H9NS | [MDL Number]
MFCD06090846 | [Molecular Weight]
127.21 | [MOL File]
30433-91-1.mol |
| Chemical Properties | Back Directory | [Appearance]
colorless to yellow liquid | [Melting point ]
202 °C | [Boiling point ]
200-201 °C/750 mmHg (lit.) | [density ]
1.087 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.551(lit.)
| [Fp ]
190 °F
| [storage temp. ]
Refrigerator (+4°C) | [solubility ]
DMSO, Methanol | [form ]
Liquid | [pka]
9.47±0.10(Predicted) | [color ]
Colorless to yellow | [Specific Gravity]
1.087 | [Sensitive ]
Air Sensitive | [Detection Methods]
GC,NMR | [BRN ]
106962 | [InChI]
1S/C6H9NS/c7-4-3-6-2-1-5-8-6/h1-2,5H,3-4,7H2 | [InChIKey]
HVLUYXIJZLDNIS-UHFFFAOYSA-N | [SMILES]
NCCc1cccs1 | [CAS DataBase Reference]
30433-91-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302+H312+H332-H315-H319-H335 | [Precautionary statements ]
P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
NA 1993 / PGIII | [WGK Germany ]
3
| [REACH Registrations]
Active | [HazardClass ]
8 | [HazardClass ]
IRRITANT | [PackingGroup ]
II | [HS Code ]
29349900 | [Storage Class]
10 - Combustible liquids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Hydrochloric acid-->Methanol-->Tetrahydrofuran-->Dichloromethane-->Potassium hydroxide-->Lithium Aluminum Hydride-->Nitromethane-->Chlorotrimethylsilane-->2-Thiophenecarboxaldehyde-->Lithium borohydride-->Acetaldoxime-->Isopropyl chloroacetate | [Preparation Products]
4,5,6,7-Tetrahydrothieno[3,2,c] pyridine hydrochloride-->5-(2-Aminoethyl)thiophene-2-sulfonamide-->Clopidogrel hydrogen sulfate-->5,6,7,7a-Tetrahydro-5-(triphenylmethyl)thieno[3,2-c]pyridinone-->2-Thiopheneacetonitrile-->Thieno[3,2-c]pyridine, 4-(5-chloro-2-thienyl)-4,5,6,7-tetrahydro- |
| Hazard Information | Back Directory | [Chemical Properties]
colorless to yellow liquid | [Uses]
[2-(Thiophene-2-yl)ethyl]amine is used in the synthesis of geldanamycin derivatives as HCV replication inhibitors targetting Hsp90. | [Uses]
2-Thiopheneethylamine (2-thiophene ethyl amine, 2-(thien-2-yl)ethylamine) is suitable to functionalize multiwall carbon nanotubes (MWCNT).
It may be used as a reactant in the synthesis of pyrimidine derivatives by reacting with various isothiocyanatoketones and acylguanidines derivatives by reacting with aroyl S-methylisothiourea. | [General Description]
2-Thiopheneethylamine (2-(thiophen-2-yl)ethanamine) is an aromatic amine. It undergoes microwave induced condensation with iminodiacetic acid to form the corresponding piperazine-2,6-dione derivatives. Its effect as a probable substitute to the pyridine ligand on the performance of poly(3-hexylthiophene)/CdSe hybrid solar cells has been investigated. | [Synthesis]
N,N-Dimethylformamide (DMF) reacts with thiophene to obtain 2-thiophenecarbaldehyde, then reacts with isopropyl chloroacetate to obtain 2-thiopheneacetaldehyde, and then reacts with hydroxylamine hydrochloride to obtain 2-thiopheneacetaldehyde oxime, and finally reduced to give 2-thiopheneethylamine. | [References]
[1] M. BARWIOLEK. Structural and spectral studies of silver(I) complexes with new Schiff bases derived from 2-thiopheneethylamine and their application in thin layer deposition by spin and dip coating techniques[J]. Polyhedron, 2017, 124: Pages 12-21. DOI:10.1016/j.poly.2016.12.011.
[2] BHUSHAN D. VARPE S B J. Schiff Base of Isatin with 2-Thiopheneethylamine and Its Mannich Bases: Synthesis, Docking, and In Vitro Anti-Inflammatory and Antitubercular Activity[J]. Russian Journal of Bioorganic Chemistry, 2022, 48 2: 372-379. DOI:10.1134/S1068162022020030.
[3] JUN YAN LEK. Understanding the Effect of Surface Chemistry on Charge Generation and Transport in Poly (3-hexylthiophene)/CdSe Hybrid Solar Cells[J]. ACS Applied Materials & Interfaces, 2011, 3 2: 287-292. DOI:10.1021/am100938f.
[4] SANDEEP KUMAR. Efficient synthesis of piperazine-2,6-dione and 4-(1H-indole-2-carbonyl)piperazine-2,6-dione derivatives and their evaluation for anticancer activity[J]. Medicinal Chemistry Research, 2013, 22 10: 4600-4609. DOI:10.1007/s00044-012-0438-7. |
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Alfa Aesar
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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