| Identification | More | [Name]
2,5-Dimethoxybenzylamine | [CAS]
3275-95-4 | [Synonyms]
2,5-DIMETHOXYBENZYLAMINE
RARECHEM AL BW 0348
2,5-dimethoxy-benzenemethanamin
2,5-dimethoxy-benzylamin
(2,5-dimethoxyphenyl)methanamine
2,5-Dimethoxybenzylamine ,98% | [Molecular Formula]
C9H13NO2 | [MDL Number]
MFCD00052811 | [Molecular Weight]
167.21 | [MOL File]
3275-95-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Boiling point ]
95 °C/0.2 mmHg (lit.) | [density ]
1.11 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.548(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Store under Nitrogen | [form ]
clear liquid | [pka]
9.12±0.10(Predicted) | [color ]
Colorless to Light orange to Yellow | [Detection Methods]
HPLC,NMR | [InChI]
1S/C9H13NO2/c1-11-8-3-4-9(12-2)7(5-8)6-10/h3-5H,6,10H2,1-2H3 | [InChIKey]
UWMCHDDHXMFKMA-UHFFFAOYSA-N | [SMILES]
COc1ccc(OC)c(CN)c1 | [CAS DataBase Reference]
3275-95-4(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive;Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2735 8/PG 3
| [WGK Germany ]
3
| [RTECS ]
DP4430000
| [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29222990 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Uses]
2,5-Dimethoxybenzylamine reacts with ethyl bromoacetate to yield N-(2,5-dimethoxy)benzylglycine ethyl ester. | [Uses]
2,5-Dimethoxybenzylamine is used in the preparation of pyrrolo[2,3-b]pyrazine-7-carboxamide derivatives as JAK and SYK inhibitors for the treatment of autoimmune and inflammatory diseases. | [Synthesis]
Hexamethylenetetramine (urotropine) (2.1 g, 15.0 mmol) was dissolved in 60 mL of chloroform and heated to reflux; 2,5-dimethoxybenzyl bromide (2.97 g, 12.9 mmol) was dissolved in 60 mL of chloroform, then dripped into urotropine within 30 min, refluxed fo |
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