| Identification | More | [Name]
Methyl 2,3-dichloropropionate | [CAS]
3674-09-7 | [Synonyms]
2,3-DICHLOROPROPIONIC ACID METHYL ESTER
METHYL 2,3-DICHLOROPROPIONATE
METHYL-A,B-DICHLOROPROPIONATE
METHYL ALPHA,BETA-DICHLOROPROPIONATE
2,3-dichloro-propanoicacimethylester
Methyl 2,3-dichloropropanoate
Propionic acid, 2,3-dichloro-, methyl ester
METHYL-2,3-DICHLOROPROPIONATE, 1000MG, N EAT
Methyl 2,3-dichloropropionate, tech., 70%
Propanoic acid, 2,3-dichloro-, methyl ester
2,3-dichloro-propanoic acid methyl ester | [EINECS(EC#)]
222-940-2 | [Molecular Formula]
C4H6Cl2O2 | [MDL Number]
MFCD00000944 | [Molecular Weight]
157 | [MOL File]
3674-09-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R10:Flammable. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
1993 | [WGK Germany ]
3
| [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29159000 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to slightly yellow liquid | [Uses]
Methyl 2,3-dichloropropionate can be used to produce 2-chloro-acrylic acid methyl ester at Heating. It is used as pharmaceutical intermediate. | [Application]
Methyl 2,3-Dichloropropanoate is a useful reagent in preparation of oxidative fragmentation and coupling of catharanthine analogs to vindoline. | [Synthesis]
Preparation of Methyl 2,3-dichloropropanoate:
Methyl acrylate (2366 g, 27.5 mol) and dimethylformamide (DMF) (40 g, 0.55 mol) was placed in a 3-liter three necked flask fitted with a stirrer, thermometer, inlet tube and gas trap. Chlorine (950 g, 0.48 mol) was passed into the methyl acrylate rapidly over a period of ten hours while the temperature was kept below 40°C. Reaction progress was monitored by gas chromatography (GC). When it seemed that 50 percent of chlorine was consumed, the reaction was stopped. The reaction mass was taken for distillation to separate methylacrylate and Methyl 2,3-dichloropropanoate. The contents were subjected to vacuum distillation. Methyl 2,3-dichloropropanoate was collected distilling at 70°C with 15mm.Yield (%):77.2, Purity (%) = 98. |
|
|