| Identification | More | [Name]
Ethyl 2,3-dibromopropionate | [CAS]
3674-13-3 | [Synonyms]
2,3-DIBROMOPROPIONIC ACID ETHYL ESTER
ETHYL 2,3-DIBROMOPROPANOATE
ETHYL 2,3-DIBROMOPROPIONATE
2,3-dibromo-propanoicaciethylester
2,3-dibromo-propionicaciethylester
Ethyl alpha,beta-dibromopropionate
ethylalpha,beta-dibromopropionate
Propanoicacid,2,3-dibromo-,ethylester
Propionic acid, 2,3-dibromo-, ethyl ester
2,3-dibromo-propanoic acid ethyl ester | [EINECS(EC#)]
222-941-8 | [Molecular Formula]
C5H8Br2O2 | [MDL Number]
MFCD00000212 | [Molecular Weight]
259.92 | [MOL File]
3674-13-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R22:Harmful if swallowed.
R24:Toxic in contact with skin.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2922 8/PG 2
| [WGK Germany ]
2
| [RTECS ]
UA2458382
| [F ]
19-21 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29159080 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Oral
Eye Dam. 1
Skin Corr. 1B | [Safety Profile]
A poison by ingestion
and skin contact. A severe skin and eye
irritant. When heated to decomposition it
emits toxic vapors of Br-.
| [Toxicity]
LD50 orally in Rabbit: 240 mg/kg LD50 dermal Rabbit 230 mg/kg |
| Hazard Information | Back Directory | [Hazard]
A poison by ingestion and skin contact. A
severe skin and eye irritant. | [Chemical Properties]
clear colorless to yellow liquid | [Uses]
Ethyl 2,3-dibromopropionate is used as pharmaceutical Intermediates. It is a building block that has been used as a catalyst for the polymerization of ethyl acrylate. | [Synthesis]
General method: A solution of 1.2 moles of carbon tetrachloride (CCl4) with bromine (Br2) was slowly added dropwise to a stirred solution of carbon tetrachloride (CCl4) containing 1 mole of ethyl acrylate at 0°C. The reaction mixture was allowed to run for 2 hours. After the dropwise addition was completed, the reaction mixture was warmed to 60 °C and refluxed for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after the reaction was complete, the solvent was evaporated under reduced pressure to give ethyl 2,3-dibromopropionate in 99% yield. | [References]
[1] Journal of Organic Chemistry, 2018,
[2] Tetrahedron Asymmetry, 2012, vol. 23, # 22-23, p. 1615 - 1623
[3] Macromolecules, 2018, vol. 51, # 11, p. 4068 - 4076
[4] Journal of Chemical Research, 2005, # 8, p. 481 - 483
[5] New Journal of Chemistry, 2013, vol. 37, # 5, p. 1343 - 1349 |
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