| Identification | More | [Name]
Ethyl 3-bromopropionate | [CAS]
539-74-2 | [Synonyms]
3-BROMOPROPIONIC ACID ETHYL ESTER
BETA-BROMOPROPIONIC ACID ETHYL ESTER
ETHYL 3-BROMOPROPIONATE
3-Bromopropanoicacidethylester
3-bromo-propanoicaciethylester
Ethyl 3-bromopropanoate
Ethyl beta-bromopropionate
Ethyl3-Bromopropanoate
Ethyl-bromopropionate
Propanoicacid,3-bromo-,ethylester
Propionic acid, 3-bromo-, ethyl ester
Ethyl3-Bromopropionate,~98%
Ethyl3-bromopropionate,99% | [EINECS(EC#)]
208-724-0 | [Molecular Formula]
C5H9BrO2 | [MDL Number]
MFCD00000251 | [Molecular Weight]
181.03 | [MOL File]
539-74-2.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to pale yellow liquid | [Melting point ]
184-186 °C(Solv: water (7732-18-5)) | [Boiling point ]
135-136 °C/50 mmHg (lit.) | [density ]
1.412 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.452(lit.)
| [Fp ]
175 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
H2O: soluble | [form ]
Liquid | [color ]
Clear colorless to pale yellow | [Water Solubility ]
Soluble in water, alcohol, chloroform, benzene. | [Sensitive ]
Light Sensitive | [BRN ]
1700933 | [Dielectric constant]
9.4（20.0℃） | [CAS DataBase Reference]
539-74-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Propanoic acid, 3-bromo-, ethyl ester(539-74-2) | [EPA Substance Registry System]
539-74-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29159000 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to pale yellow liquid | [Uses]
Ethyl 3-bromopropionate was used in the preparation of (3?,4?-dimethoxyphenyl)-5-oxopentanoic acid. | [Application]
Ethyl 3-bromopropionate is primarily used as an intermediate in organic synthesis. Due to the presence of an active bromine atom in its molecular structure, it exhibits the properties of an alkylating agent in chemical reactions, enabling it to participate in various types of chemical reactions. It is an important electrophilic reagent that can be used to introduce specific functional groups or carbon chains when constructing complex organic molecules. | [Synthesis]
The amount of 3-bromopropionic acid was fixed at 30 g. Ethanol and 3-bromopropionic acid were added to a 100 mL three-necked round-bottom flask at a molar ratio of 1.5, followed by 60 mL of benzene and 1.2 g of p-toluenesulfonic acid. The mixture was thoroughly shaken, and a condenser and water separator were connected. The mixture was refluxed at 80 °C for 3.5 h until no more water precipitated. The solvent was evaporated, 20 mL of 5% sodium bicarbonate solution was added, and the mixture was washed with 50 mL of water. The mixture was then redistilled. Ethyl 3-bromopropionate was obtained with a mass fraction of 98.49% and a yield of 94.7%. | [References]
[1] Patent: US2009/156593, 2009, A1. Location in patent: Page/Page column 10
[2] Journal of the American Chemical Society, 1934, vol. 56, p. 698
[3] Org.Synth. Coll.Vol.III<1955>577,
[4] Annales de Chimie (Cachan, France), 1921, vol. <9>15, p. 246
[5] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1921, vol. 172, p. 1269 |
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