| Identification | Back Directory | [Name]
1-(1,8-dihydroxy-3-methyl-naphthalen-2-yl)ethanone | [CAS]
3785-24-8 | [Synonyms]
Musizin
Nepodin
Musizine
NSC 365795
NEPODIN (MUSIZIN)
2-Acetyl-3-methyl-1,8-naphthalenediol
Ethanone,1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)-
1-(1,8-dihydroxy-3-methyl-naphthalen-2-yl)ethanone USP/EP/BP | [Molecular Formula]
C13H12O3 | [MDL Number]
MFCD00238579 | [MOL File]
3785-24-8.mol | [Molecular Weight]
216.23 |
| Chemical Properties | Back Directory | [Melting point ]
165-166℃ (methanol ) | [Boiling point ]
357.9±22.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
4°C, protect from light | [solubility ]
Methanol: soluble | [form ]
A solid | [pka]
5.13±0.50(Predicted) | [color ]
White to yellow | [InChI]
InChI=1S/C13H12O3/c1-7-6-9-4-3-5-10(15)12(9)13(16)11(7)8(2)14/h3-6,15-16H,1-2H3 | [InChIKey]
DMLHPCALHMPJHS-UHFFFAOYSA-N | [SMILES]
C(=O)(C1=C(C)C=C2C(=C1O)C(O)=CC=C2)C |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow crystals, soluble in methanol, ethanol, ethyl acetate, insoluble in water, derived from the root of the Polygonaceae plant Rhizoma Cibotii or Rhizoma Nepalensis. | [Uses]
1-(1,8-Dihydroxy-3-methyl-naphthalen-2-yl)-ethanone is a naphthalene for proteomics research. | [Definition]
ChEBI: Nepodin is a member of naphthols. | [in vivo]
Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2]. | Animal Model: | C57BL/KsJ-db/db mice[2] | | Dosage: | 2 mg/kg; 10 mg/kg | | Administration: | Orally administration; 2-10 mg/kg; 4 weeks | | Result: | Had antihyperglycemic potential and improved insulin resistance. |
| [IC 50]
Plasmodium | [storage]
4°C, protect from light |
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