| Identification | More | [Name]
Tulobuterol | [CAS]
41570-61-0 | [Synonyms]
alpha-[(tert-butylamino)methyl]-o-chlorobenzyl alcohol
TULOBUTEROL
TULOBUTEROL BASE
TulobuterolHcl56776-01-3/Base
Tulobuterol(baseandorunspecifiedsalt)
2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethano
Benzenemethanol, 2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-(9CI)
HN 078
o-Chloro-a-[(tert-butylamino)methyl]benzyl alcohol
Tulobuterol Bane
Tulobuterol (base and/or unspecified salts)
2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol
2-(tert-Butylamino)-1-(o-chlorophenyl)ethanol
Sekinarin
Tulobunist
Tulobuten
α-[(tert-Butylamino)methyl]-2-chlorobenzenemethanol | [Molecular Formula]
C12H18ClNO | [MDL Number]
MFCD00867022 | [Molecular Weight]
227.73 | [MOL File]
41570-61-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
89-91°C | [Boiling point ]
338.2±27.0 °C(Predicted) | [density ]
1.098±0.06 g/cm3(Predicted) | [RTECS ]
DA4734170 | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.62±0.20(Predicted) | [color ]
White to Off-White | [Usage]
A ?adrenergic receptor agonist, related structurally to Terbutaline | [InChI]
InChI=1S/C9H6F3IN2O2S/c1-18(16,17)15-8-3-6(9(10,11)12)5(4-14)2-7(8)13/h2-3,15H,1H3 | [InChIKey]
YREYLAVBNPACJM-UHFFFAOYSA-N | [SMILES]
Clc1c(cccc1)C(O)CNC(C)(C)C | [CAS DataBase Reference]
41570-61-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
24/25 | [HS Code ]
29214990 | [Storage Class]
11 - Combustible Solids | [Toxicity]
LD50 in male mice, rats, rabbits (mg/kg): 305, 850, 563 orally; 170, 417, 164 s.c. (Kubo, 1975) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Uses]
A ?adrenergic receptor agonist, related structurally to Terbutaline | [Uses]
A sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength. A β-adrenergic receptor agonist, related structurally to Terbutaline (T109750). | [Uses]
Tulobuterol is a sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength.
| [Definition]
ChEBI: 2-(tert-butylamino)-1-(2-chlorophenyl)ethanol is an organochlorine compound. | [in vivo]
In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h[2]. | [IC 50]
β adrenergic receptor |
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AFINE CHEMICALS LIMITED
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www.afinechem.com/index.html |
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