| Identification | More | [Name]
Ethyl difluoroacetate | [CAS]
454-31-9 | [Synonyms]
AKOS B020251
ART-CHEM-BB B020251
DIFLUOROACETIC ACID ETHYL ESTER
ETHYL DIFLUOROACETATE
ETHYL DIFLUOROACETIC ACID
difluoro-aceticaciethylester
ETHYL DIFLUOROACETATE 97%
Ethyldifluoroacetate,98%
Ethyl difluoroacetic
Ethyldifluoroacetate,min.97%
Ethyldifluoroacetate, min. 97% | [EINECS(EC#)]
207-223-4 | [Molecular Formula]
C4H6F2O2 | [MDL Number]
MFCD00013578 | [Molecular Weight]
124.09 | [MOL File]
454-31-9.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Boiling point ]
99.2 °C (lit.) | [density ]
1.242
| [vapor pressure ]
30.03-200.2hPa at 20.03-56.98℃ | [refractive index ]
1.3465-1.3485
| [Fp ]
25 °C
| [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Sparingly), Methanol (Sparingly) | [form ]
Liquid | [color ]
Clear colorless | [Specific Gravity]
1.242 | [Water Solubility ]
Slightly soluble in water | [BRN ]
1748597 | [InChI]
1S/C4H6F2O2/c1-2-8-4(7)3(5)6/h3H,2H2,1H3 | [InChIKey]
GZKHDVAKKLTJPO-UHFFFAOYSA-N | [SMILES]
CCOC(=O)C(F)F | [LogP]
0.87 at 25℃ | [CAS DataBase Reference]
454-31-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Acetic acid, difluoro-, ethyl ester(454-31-9) | [EPA Substance Registry System]
454-31-9(EPA Substance) |
| Questions And Answer | Back Directory | [Preparation]
Currently, there are many methods for preparing Ethyl difluoroacetate, including the following: Method 1, EP0694523 discloses a method for preparing Ethyl difluoroacetate. This method involves the addition of tetrafluoroethylene to methanol under catalysis to synthesize methoxytetrafluoroethane. The methoxytetrafluoroethane is then catalytically cracked to obtain difluoroacetyl fluoride, which is then esterified with ethanol to obtain Ethyl difluoroacetate. |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS05 | [Signal word ]
Danger | [Hazard statements ]
H226-H314 | [Precautionary statements ]
P210-P233-P240-P280-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
C,F,T,Xi | [Risk Statements ]
R34:Causes burns.
R10:Flammable. | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
1992 | [WGK Germany ]
3 | [Hazard Note ]
Flammable | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29159000 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Flam. Liq. 3
Skin Corr. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
Ethyl difluoroacetate is used in pharmaceutical intermediates, acrylization oxidation and halogenating reaction of catalyst. Also ethyl difluoroacetate is used in preparing pyrrazolo-pyrimidine derivatives. | [General Description]
Ethyl difluoroacetate was degraded to difluoroacetic acid by the strains of Actinobacteria. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|