| Identification | More | [Name]
Ethyl 6-chloronicotinate | [CAS]
49608-01-7 | [Synonyms]
6-CHLORONICOTINIC ACID ETHYL ESTER
ETHYL 6-CHLORONICOTINATE
6-Chloro Nitotinic acid Ethyl ester
6-Chloronicotinic acid ethyl ester (Ethyl-6-Chloronicotinate)
Ethyl6-chloronicotinate,97%
3-Pyridinecarboxylic acid, 6-chloro-, ethyl ester
ETHYL 6-CHLORONICOTINATE[FOR TAZAROTENE]
Ethyl 6-chloropyridine-3-carboxylate
ETHYL 2-CHLOROPYRIDINE-5-CARBOXYLATE
Ethyl 2-chloropyridine-3-carboxylate, 6-Chloronicotinic acid ethyl ester
Ethyl 6-chloropyridine-3-carboxylate ,98%
6-Chloro-3-pyridinecarboxylic acid ethyl ester | [EINECS(EC#)]
610-463-6 | [Molecular Formula]
C8H8ClNO2 | [MDL Number]
MFCD00082739 | [Molecular Weight]
185.61 | [MOL File]
49608-01-7.mol |
| Questions And Answer | Back Directory | [Synthesis]
50 g (0.317 mol) of 6-chloronicotinic acid, 500 ml of acetonitrile, and 56.6 g (0.35 mol) of carbonyl diimidazole were stirred at room temperature for 2 h. Then, 52 ml (0.8 mol) of ethanol was added to the solution, and stirring continued for 2 h. The reaction progress was monitored by TLC. After the reaction was complete, the solvent was removed under vacuum. The residue was dissolved in 1 L of dichloromethane. The resulting dichloromethane layer was washed with water and then with a saturated sodium bicarbonate aqueous solution. The organic layer was dried over anhydrous sodium sulfate, and the sodium sulfate solid was removed by filtration. The filtrate was concentrated under reduced pressure to obtain the target compound. |
| Chemical Properties | Back Directory | [Melting point ]
26-30 °C(lit.)
| [Boiling point ]
98 °C | [density ]
1.245±0.06 g/cm3(Predicted) | [refractive index ]
1.522 | [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
-1.95±0.10(Predicted) | [color ]
Colourless to Off-White Oil | [Detection Methods]
HPLC | [BRN ]
4742175 | [InChI]
1S/C8H8ClNO2/c1-2-12-8(11)6-3-4-7(9)10-5-6/h3-5H,2H2,1H3 | [InChIKey]
ILDJJTQWIZLGPO-UHFFFAOYSA-N | [SMILES]
CCOC(=O)c1ccc(Cl)nc1 | [CAS DataBase Reference]
49608-01-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
White to light yellow solid or colorless to yellow liquid | [Uses]
Ethyl 6-chloropyridine-3-carboxylate (Ethyl 6-chloronicotinate) may be used in the preparation of ethyl 5-{[5-(1H-benzimidazol-2-yl)pyridin-2-yl]ethynyl}pyridine-2-carboxylate by reacting with 2-[6-(ethynyl)pyridin-3-yl]-1H-benzimidazole under microwave irradiation. | [Uses]
Ethyl 6-chloronicotinate is a nicotinic acid derivative used in the preparation of potent H3 receptor antagonists.
| [General Description]
Ethyl 6-chloropyridine-3-carboxylate (Ethyl-6-chloronicotinate, E-6-ClN) undergoes direct amidation on reacting with benzylamine in the presence lanthanum trifluoromethanesulfonate La(OTf)3. The structural and physicochemical properties of E-6-ClN have been investigated based on its spectroscopic data, time-dependent density functional theory and density of state diagrams. |
|
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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