| Identification | More | [Name]
3(2H)-Pyridazinone | [CAS]
504-30-3 | [Synonyms]
2H-PYRIDAZIN-3-ONE
3(2H)-PYRIDAZINONE
3-HYDROXYPYRIDAZINE
PYRIDAZIN-3-OL
TIMTEC-BB SBB005360
2H-Pyridazine-3-One
3-(2H)-PYRIDAZINE-3-ONE,PYRIDAZIN-3(2H)-ONE,3(2H)-PYRIDAZINONE
3(2H)-PYRIDAZINONE 97+%
Pyridazin-3(2H)-one
2,3-Dihydropyridazine-3-one
Pyridazine-3-ol | [Molecular Formula]
C4H4N2O | [MDL Number]
MFCD01646051 | [Molecular Weight]
96.09 | [MOL File]
504-30-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
98-104 °C | [Boiling point ]
101°C/1.5mmHg(lit.) | [density ]
1.478 g/cm3 | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
11.47±0.20(Predicted) | [color ]
Light Red to Light Brown | [λmax]
290nm(EtOH)(lit.) | [BRN ]
106974 | [InChI]
InChI=1S/C4H4N2O/c7-4-2-1-3-5-6-4/h1-3H,(H,6,7) | [InChIKey]
AAILEWXSEQLMNI-UHFFFAOYSA-N | [SMILES]
C1(=O)NN=CC=C1 | [CAS DataBase Reference]
504-30-3(CAS DataBase Reference) | [NIST Chemistry Reference]
3(2H)-pyridazinone(504-30-3) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338-P280a-P304+P340-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3
| [HS Code ]
29339900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
Pyridazin-3(2H)-one can be used for anti-inflammatory and analgesic drug discovery. | [Synthesis]
III. A finely ground mixture of 6-(3-allyl-4-hydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone (50 g, 0.22 mol), epichlorohydrin (200 g, 2.2 mol) and piperidine (2 g) was heated on a steam bath for 90 minutes. Upon completion of the reaction, the volatile components were removed by evaporation under reduced pressure to give a viscous oily substance. The oily substance was dissolved in dichloromethane and subsequently washed with dilute sodium hydroxide solution (500 mL) with agitation for 10 minutes. The organic phase was separated, washed with water, dried over anhydrous sodium sulfate, and the solvent was evaporated to obtain the oily substance, which gradually solidified during standing. Addition of ethanol ether to the solid afforded 6-[3-allyl-4-(2,3-epoxypropoxy)phenyl]-4,5-dihydro-3(2H)-pyridazinone (30 g, 47% yield, melting point 92.5°-95°C). The pure pyridazinone (melting point 93.5°-95°C) was further obtained by recrystallization from aqueous ethanol. The results of the elemental analyses were as follows: measured values (C, 67.41; H, 6.47; N, 9.80; M+, 286), which are in agreement with the theoretical values (C16H18N2O3: C, 67.11; H, 6.33; N, 9.79; M, 286). | [References]
[1] Patent: US3931177, 1976, A |
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