| Identification | More | [Name]
2-Amino-5-hydroxypyridine | [CAS]
55717-46-9 | [Synonyms]
2-AMINO-5-HYDROXYPYRIDINE
6-AMINO-PYRIDIN-3-OL
IFLAB-BB F1921-0034
2-amino-5-hydroxypryidine
2-aminopyridin-5-ol
6-AMINO-3-HYOXYPYRIDINE
6-Amino-pyridin-3-ol hydrobromide
5-Hydroxy-2-pyridinamine
6-Amino-3-pyridinol | [EINECS(EC#)]
692-865-1 | [Molecular Formula]
C5H6N2O | [MDL Number]
MFCD03541056 | [Molecular Weight]
110.11 | [MOL File]
55717-46-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Light yellow Cryst | [Melting point ]
116-117 °C(Solv: methanol (67-56-1); benzene (71-43-2)) | [Boiling point ]
447.4±30.0 °C(Predicted) | [density ]
1.320±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Powder | [pka]
10.47±0.10(Predicted) | [InChI]
InChI=1S/C5H6N2O/c6-5-2-1-4(8)3-7-5/h1-3,8H,(H2,6,7) | [InChIKey]
ZTWYBFHLUJUUDX-UHFFFAOYSA-N | [SMILES]
C1=NC(N)=CC=C1O | [CAS DataBase Reference]
55717-46-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Chemical Properties]
2-Amino-5-hydroxypyridine is Light yellow Cryst
| [Uses]
2-Amino-5-hydroxypyridine is a substituted pyridine used as an efficient antioxidant in human low density lipoproteins.
| [Synthesis]
The general procedure for the synthesis of 2-amino-5-hydroxypyridine from 5-(benzyloxy)pyridin-2-amine was as follows: 2-amino-5-benzyloxypyridine, ethanol (217 g) and a toluene solution (331 g) of 10% Pd/C (2.28 g, 53% moisture content) were added to an autoclave and the reaction was carried out at 25 °C. During the reaction, hydrogen was introduced into the autoclave, maintaining an absolute pressure of 0.2 MPa, and the reaction lasted for several hours. Upon completion of the reaction, the Pd/C catalyst was removed by filtration and the residue was washed with ethanol (76 g). The filtrate was dried under reduced pressure to give 2-amino-5-hydroxypyridine (25.6 g, 0.23 mol) in 92% yield. | [References]
[1] Patent: JP2017/48131, 2017, A. Location in patent: Paragraph 0124 |
|
|