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55717-46-9

55717-46-9 Structure

55717-46-9 Structure
IdentificationMore
[Name]

2-Amino-5-hydroxypyridine
[CAS]

55717-46-9
[Synonyms]

2-AMINO-5-HYDROXYPYRIDINE
6-AMINO-PYRIDIN-3-OL
IFLAB-BB F1921-0034
2-amino-5-hydroxypryidine
2-aminopyridin-5-ol
6-AMINO-3-HYOXYPYRIDINE
6-Amino-pyridin-3-ol hydrobromide
5-Hydroxy-2-pyridinamine
6-Amino-3-pyridinol
[EINECS(EC#)]

692-865-1
[Molecular Formula]

C5H6N2O
[MDL Number]

MFCD03541056
[Molecular Weight]

110.11
[MOL File]

55717-46-9.mol
Chemical PropertiesBack Directory
[Appearance]

Light yellow Cryst
[Melting point ]

116-117 °C(Solv: methanol (67-56-1); benzene (71-43-2))
[Boiling point ]

447.4±30.0 °C(Predicted)
[density ]

1.320±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[form ]

Powder
[pka]

10.47±0.10(Predicted)
[InChI]

InChI=1S/C5H6N2O/c6-5-2-1-4(8)3-7-5/h1-3,8H,(H2,6,7)
[InChIKey]

ZTWYBFHLUJUUDX-UHFFFAOYSA-N
[SMILES]

C1=NC(N)=CC=C1O
[CAS DataBase Reference]

55717-46-9(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H332-H335
[Precautionary statements ]

P261-P280-P305+P351+P338
[Hazard Codes ]

Xn
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
[HS Code ]

2933399990
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ethanol-->Hydrochloric acid-->Methanol-->Diethyl ether-->Acetic anhydride-->Benzene-->Potassium permanganate-->Hydrazinium hydroxide solution-->5-Amino-2-methylpyridine-->2-Amino-3-picoline-->1-Butyl nitrite
[Preparation Products]

5-(cyclopentyloxy)-2-Pyridinamine
Hazard InformationBack Directory
[Chemical Properties]

2-Amino-5-hydroxypyridine is Light yellow Cryst
[Uses]

2-Amino-5-hydroxypyridine is a substituted pyridine used as an efficient antioxidant in human low density lipoproteins.
[Synthesis]

5-(benzyloxy)pyridin-2-amine

96166-00-6

2-Amino-5-hydroxypyridine

55717-46-9

The general procedure for the synthesis of 2-amino-5-hydroxypyridine from 5-(benzyloxy)pyridin-2-amine was as follows: 2-amino-5-benzyloxypyridine, ethanol (217 g) and a toluene solution (331 g) of 10% Pd/C (2.28 g, 53% moisture content) were added to an autoclave and the reaction was carried out at 25 °C. During the reaction, hydrogen was introduced into the autoclave, maintaining an absolute pressure of 0.2 MPa, and the reaction lasted for several hours. Upon completion of the reaction, the Pd/C catalyst was removed by filtration and the residue was washed with ethanol (76 g). The filtrate was dried under reduced pressure to give 2-amino-5-hydroxypyridine (25.6 g, 0.23 mol) in 92% yield.

[References]

[1] Patent: JP2017/48131, 2017, A. Location in patent: Paragraph 0124
Spectrum DetailBack Directory
[Spectrum Detail]

2-Amino-5-hydroxypyridine(55717-46-9)1HNMR
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