| Identification | Back Directory | [Name]
Ethyl thiophene-3-carboxylate | [CAS]
5751-80-4 | [Synonyms]
THOO2
3-thenoate
ethyl 3-thenoate
RARECHEM AL BI 0549
ETHYL 3-THIENYLACETATE
ETHYL 3-THIOPHENEACETATE
ETHYL THIOPHENE-3-ACETATE
Thiophene -3-ethyl forMate
ETHYL THIOPHENE-3-CARBOXYLATE
Ethylthiophene-3-carboxylate,98%
Thiophene -3- formic acid ethyl ester
3-Thiophenecarboxylic acid ethyl ester
thiophene-3-carboxylic acid ethyl ester
Ethyl thiophene-3-carboxylate ISO 9001：2015 REACH
7-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-4-(prop-2-enylthio)-5-pyrrolo[2,3-d]pyrimidinecarbonitrile | [EINECS(EC#)]
227-275-1 | [Molecular Formula]
C7H8O2S | [MDL Number]
MFCD00005472 | [MOL File]
5751-80-4.mol | [Molecular Weight]
156.2 |
| Chemical Properties | Back Directory | [Boiling point ]
97-98 °C (8 mmHg)
| [density ]
1.12
| [refractive index ]
1.509-1.511
| [Fp ]
103 °C
| [storage temp. ]
0-6°C | [form ]
clear liquid | [color ]
Colorless to Light yellow to Light orange | [Water Solubility ]
Soluble in water. |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid | [Uses]
Ethyl thiophene-3-carboxylate is used as an intermediate in organic syntheses | [Synthesis]
Thirteen mL (200 mmol) of thionyl chloride was added slowly and dropwise at 0 °C to a 100 mL ethanol solution containing 9 g (70 mmol) of 3-thiophenecarboxylic acid and 86 mg (0.7 mmol) of 4-dimethylaminopyridine. The reaction mixture was gradually warmed from 0 °C to room temperature over 48 h with continuous stirring. Subsequently, the reaction solution was evaporated to dryness. The resulting residue was purified by silica column chromatography with the eluent being a 1:1 heptane/dichloromethane solvent mixture. Finally 10 g (91% yield) of ethyl thiophene-3-carboxylate was obtained. | [References]
[1] Patent: WO2004/113331, 2004, A1. Location in patent: Page 38-39
[2] Organic Process Research and Development, 2017, vol. 21, # 7, p. 947 - 955
[3] Organic Letters, 2008, vol. 10, # 9, p. 1851 - 1854
[4] Angewandte Chemie - International Edition, 2017, vol. 56, # 33, p. 9924 - 9929
[5] Angew. Chem., 2017, vol. 129, p. 10056 - 10061,6 |
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