| Identification | More | [Name]
4-Hydroxy-2-butanone | [CAS]
590-90-9 | [Synonyms]
2-HYDROXYETHYL METHYL KETONE
4-HYDROXY-2-BUTANONE
2-Butanone, 4-hydroxy-
2-Butanone,4-hydroxy-
3-Ketobutan-1-ol
3-Oxo-1-butanol
3-Oxobutanol
4-Butanol-2-one
4-hydroxy-2-butanon
CH3C(O)CH2CH2OH
Methylolacetone
Monomethylolacetone
4-hydroxybutan-2-one
4-Hydroxy-2-butanone,95%
ketobutanol
1-Hydroxy-3-butanone | [EINECS(EC#)]
209-693-6 | [Molecular Formula]
C4H8O2 | [MDL Number]
MFCD00059005 | [Molecular Weight]
88.11 | [MOL File]
590-90-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
15°C (estimate) | [Boiling point ]
73-76 °C/12 mmHg (lit.) | [density ]
1.023 | [refractive index ]
1.430 | [Fp ]
91°F | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform, Methanol (Slightly) | [form ]
Oil | [pka]
14.43±0.10(Predicted) | [color ]
Clear Colourless | [Water Solubility ]
Miscible with water, alcohol, ethanol and ether. | [BRN ]
1737666 | [InChI]
1S/C4H8O2/c1-4(6)2-3-5/h5H,2-3H2,1H3 | [InChIKey]
LVSQXDHWDCMMRJ-UHFFFAOYSA-N | [SMILES]
CC(=O)CCO | [LogP]
-1.209 at 25℃ | [CAS DataBase Reference]
590-90-9(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Hydroxy-2-butanone(590-90-9) | [EPA Substance Registry System]
590-90-9(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Colourless to pale yellow liquid | [Uses]
4-Hydroxy-2-butanone is used in the preparation of fused benzazepine molecules as selective D3 receptor antagonists with pharmaceutical activity. It is also used in the preparation of verrucarin and mevalonic acid lactone. Further, it is used to prepare 3-buten-2-one through dehydration over an anatase titanium dioxide catalyst. It is also employed in the preparation of 4-methyl-5-hydroxymethylthiazole, (±)-lineatin and beta-hydroxylactones. | [Application]
4-Hydroxy-2-butanone has been used in the synthesis of:- 3-buten-2-one via dehydration over anatase-TiO2 catalyst
- 4-methyl-5-hydroxymethylthiazole
- (±)-lineatin
- mevalonic acid lactone
- verrucarin
- β-hydroxylactones
| [Definition]
ChEBI: A beta-hydroxy ketone that is butan-2-one substituted by a hydroxy group at position 4. | [General Description]
4-Hydroxy-2-butanone is an important pharmaceutical intermediate. Gas phase reaction of the OH radicals with 4-hydroxy-2-butanone has been investigated by absolute rate method. | [Synthesis]
A method for synthesizing 4-hydroxy-2-butanone, comprising the steps of:
(1) adding a certain amount of 1.3 butanediol, catalyst, water and water-carrying agent to a reaction vessel, stirring well to form a mixed solution, and raising temperatu |
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