| Identification | More | [Name]
1-Benzyl-3-aminopiperidine | [CAS]
60407-35-4 | [Synonyms]
1-BENZYL-3-AMINOPIPERIDINE
1-BENZYL-3-PIPERIDINAMINE
1-BENZYLPIPERIDIN-3-AMINE
1-BENZYL-PIPERIDIN-3-YLAMINE
3-AMINO-1-BENZYLPIPERIDINE
3-AMINO-1-PHENYLMETHYLPIPERIDINE
3-Amino-1-benzylpiperidine 2HCl
1-BENZYLPIPERIDINE-3-AMINE
1-benzyl-piperidine-3-ylamine | [Molecular Formula]
C12H18N2 | [MDL Number]
MFCD04038444 | [Molecular Weight]
190.28 | [MOL File]
60407-35-4.mol |
| Chemical Properties | Back Directory | [Boiling point ]
82°C/0.01mmHg(lit.) | [density ]
1.037±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
powder to lump | [pka]
10.21±0.20(Predicted) | [color ]
White to Almost white | [CAS DataBase Reference]
60407-35-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Synthesis]
Step 2: Preparation of 3-amino-1-benzylpiperidine
2.13 g of 3-(N-acetylamino)-1-benzylpiperidine was dissolved in 10 mL of 6 N hydrochloric acid and the reaction was stirred under reflux conditions for 1 hr. After completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 9-10 by slow addition of 6 N aqueous ammonia solution.Subsequently, the mixture was extracted four times with chloroform (15 mL each time), the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure to give 1.21 g of 3-amino-1-benzylpiperidine in 96.3% yield. The product was characterized by 1H NMR (CDCl3): δ 7.31 (m, 5H), 3.51 (s, 2H), 2.93-2.61 (m, 3H), 2.06 (t, 1H), 1.90-1.52 (m, 4H), 1.20-1.02 (m, 1H) ppm. | [References]
[1] Patent: EP2754655, 2014, A2. Location in patent: Paragraph 0086; 0088
[2] Patent: US2014/256711, 2014, A1. Location in patent: Paragraph 0201; 0203 |
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