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72-18-4

72-18-4 Structure

72-18-4 Structure
IdentificationMore
[Name]

L-Valine
[CAS]

72-18-4
[Synonyms]

2-AMINO-3-METHYLBUTANOIC ACID
2-AMINOISOVALERIC ACID
H-L-VAL-OH
H-VAL-OH
L-2-AMINO-3-METHYLBUTANOIC ACID
L-2-AMINO-3-METHYLBUTYRIC ACID
L-2-AMINOISOVALERIC ACID
L-A-AMINOISOVALERIC ACID
L-ALPHA-AMINOISOVALERIANIC ACID
L-(+)-VALINE
L-VALINE
L-VLA
(S)-ALPHA-AMINOISOVALERIC ACID
(S)-(+)-VALINE
VAL
VALINE
VALINE, L-
(s)-2-amino-3-methylbutanoicacid
(S)-2-Amino-3-methylbutansαure
(s)-2-amino-3-methylbutyricacid
[EINECS(EC#)]

200-773-6
[Molecular Formula]

C5H11NO2
[MDL Number]

MFCD00064220
[Molecular Weight]

117.15
[MOL File]

72-18-4.mol
Chemical PropertiesBack Directory
[Appearance]

White crystalline powder
[Appearance]

White or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol.
[mp ]

295-300 °C (subl.)(lit.)
[alpha ]

28 º (c=8, 6N HCl)
[density ]

1.23
[refractive index ]

28 ° (C=8, HCl)
[storage temp. ]

Store at RT.
[solubility ]

H2O: 25 mg/mL
[form ]

powder
[Water Solubility ]

85 g/L (20 ºC)
[Merck ]

14,9909
[BRN ]

1721136
[Uses]

valine is an amino acid used as a skin-conditioning and odor-masking agent. It is more commonly used in hair care preparations than in skin care.
[CAS DataBase Reference]

72-18-4(CAS DataBase Reference)
[NIST Chemistry Reference]

Valine(72-18-4)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R40:Limited evidence of a carcinogenic effect.
[Safety Statements ]

S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S22:Do not breathe dust .
[WGK Germany ]

3
[RTECS ]

YV9361000
[HS Code ]

29224995
[Safety Profile]

Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Raw materials And Preparation ProductsBack Directory
【Raw materials】

Urea-->D(+)-Glucose-->2-Methyl-1-propanol-->Isobutyraldehyde-->HYDROGEN CYANIDE-->L-Glutamic acid-->Ammonium carbonate-->Isobutyronitrile-->Hydantoin-->DL-Valine-->Valine
【Preparation Products】

(S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID-->(S)-2-(Boc-amino)-3-methylbutyric acid
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

2-Aminoisovaleric acid(72-18-4).msds
Questions And AnswerBack Directory
[Amino acids]

L-Valine is a kind of branched-chain amino acids (BCAA). Animal cannot synthesize it by itself. It must be obtained from the diet to meet their nutritional needs. Therefore L-valine belongs to the essential amino acids.
Amino acids are the basic structural unit of protein synthesis, and the predecessor of other amines that metabolism needs. They are indispensable materials in our life. At present, it is known that there are 20 to 30 amino acids. Some of them can be synthesized in the human body, which are known as non-essential amino acids. And some, called essential amino acids, cannot be synthesized in the human body that should be supplemented from the outside. Mammal cells need twelve essential amino acids: L-arginine, L-cystine, L-histidine, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L-valine. These amino acids are all laevoisomer, and some non-essential amino acids of dextroisomer may have inhibitory effect on cultured cells.
L-amino acids can easier to be absorbed than D-amino acids. And the absorption of D, L-methionine has no difference. There is competition between the body transport of amino acids. The transporting of an amino acid can be suppressed by the presence of another amino acid. For example, L-valine and L-methionine can inhibit the absorption of L-leucine. Excessive lysine in dietary can inhibit the absorption of arginine. High concentration (100mM) of L-valine has no effect on the absorption of L-methionine. Because it can be transported through another route.
[Content Analysis]

About 200mg sample is accurately weighed, dissolved in 3ml formic acid and 50ml glacial acetic acid. Add 2 drops of crystal violet test solution (TS-74), then use 0.1mol/L perchloric acid to titrate the solution to green or blue disappear entirely. Each Ml0.1mol/L perchloric acid is equivalent to 11.72mg L-valine (C5H11NO2).
[Chemical property]

White crystal or crystalline powder, odorless, bitter taste. Soluble in water, solubility in water of 8.85% at 25℃. Almost insoluble in ethanol, ether, acetone. melting point(decomposition point) 315℃, isoelectric point 5.96, [α]25D+28.3 (C = 1-2g/ml, in 5mol/L HCl).
[Uses]

  • Amino acids drugs, nutritional supplements. It can be used as the main component of aminophenol transfusion and synthesize aminophenol. L-Valine is one of the three branched-chain amino acids. It is essential amino acid. It can be used to treat liver failure and central nervous system dysfunction.
  • L-Valine is essential amino acid. The requirement for men is 10mg/(kg·d). Physiological effects of the L-form is 2 times of the D-type. L-Valine deficiency can cause neurological disorders, blastocolysis, loss of weight, anemia and the like. As nutritional supplements, it can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion. Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine is the essential amino acid. It can be used as one of pharmaceutical composition of amino acid infusion to synthesize drugs. It also can be used as food additives.
  • Nutritional supplements. It can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion.Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine can be used for biochemical research, the preparation of tissue culture media. It also used as amino acids nutritional drugs in medicine.
Spectrum DetailBack Directory
[Spectrum Detail]

L-Valine(72-18-4) Raman
L-Valine(72-18-4) IR1
L-Valine(72-18-4) MS
L-Valine(72-18-4) IR2
L-Valine(72-18-4) 13C NMR
L-Valine(72-18-4) ESR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

L-Valine, 99%(72-18-4)
[Alfa Aesar]

L-Valine, 99%(72-18-4)
[Sigma Aldrich]

72-18-4(sigmaaldrich)
[TCI AMERICA]

L-Valine,>98.0%(T)(72-18-4)
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