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72-18-4

72-18-4 Structure

72-18-4 Structure
IdentificationMore
[Name]

L-Valine
[CAS]

72-18-4
[Synonyms]

2-AMINO-3-METHYLBUTANOIC ACID
2-AMINOISOVALERIC ACID
H-L-VAL-OH
H-VAL-OH
L-2-AMINO-3-METHYLBUTANOIC ACID
L-2-AMINO-3-METHYLBUTYRIC ACID
L-2-AMINOISOVALERIC ACID
L-A-AMINOISOVALERIC ACID
L-ALPHA-AMINOISOVALERIANIC ACID
L-(+)-VALINE
L-VALINE
L-VLA
(S)-ALPHA-AMINOISOVALERIC ACID
(S)-(+)-VALINE
VAL
VALINE
VALINE, L-
(s)-2-amino-3-methylbutanoicacid
(S)-2-Amino-3-methylbutansαure
(s)-2-amino-3-methylbutyricacid
[EINECS(EC#)]

200-773-6
[Molecular Formula]

C5H11NO2
[MDL Number]

MFCD00064220
[Molecular Weight]

117.15
[MOL File]

72-18-4.mol
Chemical PropertiesBack Directory
[Appearance]

White or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol.
[Melting point ]

295-300 °C (subl.) (lit.)
[alpha ]

28 º (c=8, 6N HCl)
[Boiling point ]

213.6±23.0 °C(Predicted)
[density ]

1.23
[refractive index ]

28 ° (C=8, HCl)
[storage temp. ]

Store at RT.
[solubility ]

H2O: 25 mg/mL
[form ]

powder
[pka]

2.29(at 25℃)
[color ]

White
[PH]

5.5-6.5 (100g/l, H2O, 20℃)
[optical activity]

[α]20/D +27.0±0.5°, c = 5% in 5 M HCl
[Water Solubility ]

85 g/L (20 ºC)
[λmax]

λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.1
[Merck ]

14,9909
[BRN ]

1721136
[InChIKey]

KZSNJWFQEVHDMF-BYPYZUCNSA-N
[Uses]

valine is an amino acid used as a skin-conditioning and odor-masking agent. It is more commonly used in hair care preparations than in skin care.
[CAS DataBase Reference]

72-18-4(CAS DataBase Reference)
[NIST Chemistry Reference]

Valine(72-18-4)
[EPA Substance Registry System]

L-Valine (72-18-4)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R40:Limited evidence of a carcinogenic effect.
[Safety Statements ]

S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S22:Do not breathe dust .
[WGK Germany ]

3
[RTECS ]

YV9361000
[TSCA ]

Yes
[HS Code ]

29224995
[Safety Profile]

Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
[Hazardous Substances Data]

72-18-4(Hazardous Substances Data)
[Toxicity]

LD50 intraperitoneal in rat: 5390mg/kg
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Urea-->D(+)-Glucose-->2-Methyl-1-propanol-->Isobutyraldehyde-->HYDROGEN CYANIDE-->L-Glutamic acid-->Ammonium carbonate-->Isobutyronitrile-->Hydantoin-->DL-Valine-->Valine-->L-Serine-->L-Isoleucine
[Preparation Products]

(S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID-->N-Boc-L-valine-->FMOC-L-Valine-->L-Valine, N-(2-deoxy-D-glucos-2-yl)- (9CI)-->Boc-N-methyl-L-valine
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

2-Aminoisovaleric acid(72-18-4).msds
Hazard InformationBack Directory
[Description]

Valine (abbreviated as Val or V) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. L-Valine is one of 20 proteinogenic amino acids. Its codons are GUU, GUC, GUA, and GUG. This essential amino acid is classified as nonpolar. Human dietary sources are any proteinaceous foods such as meats, dairy products, soy products, beans and legumes.
Along with leucine and isoleucine, valine is a branched-chain amino acid. It is named after the plant valerian. In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. Because valine is hydrophobic, the hemoglobin is prone to abnormal aggregation.
[Chemical Properties]

White or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol.
[Definition]

ChEBI: The L-enantiomer of valine.
[Biosynthesis]

Valine is an essential amino acid, hence it must be ingested, usually as a component of proteins. It is synthesized in plants via several steps starting from pyruvic acid. The initial part of the pathway also leads to leucine. The intermediate α-ketoisovalerate undergoes reductive amination with glutamate. Enzymes involved in this biosynthesis include :
Acetolactate synthase
Acetohydroxy acid isomeroreductase
Dihydroxyacid dehydratase
Valine aminotransferase.
[Synthesis Reference(s)]

Tetrahedron Letters, 22, p. 2411, 1981 DOI: 10.1016/S0040-4039(01)82922-1
Chemical and Pharmaceutical Bulletin, 23, p. 167, 1975 DOI: 10.1248/cpb.23.167
[General Description]

Valine is an essential amino acid, involved in the biosynthesis of glutamine and alanine. Valine being a branched-chain amino acid (BCAA), maintains a balance among the BCAAs. L-Valine serves as an energy fuel.
[Biochem/physiol Actions]

Valine is an essential amino acid, involved in the biosynthesis of glutamine and alanine. Valine being a branched-chain amino acid (BCAA) maintains a balance among the BCAAs. L-Valine serves as an energy fuel. Long term deficiency of L-Valine leads to growth failure, organ damage and loss of muscle mass.
[Synthesis]

Racemic valine can be synthesized by bromination of isovaleric acid followed by amination of the α-bromo derivative
HO2CCH2CH(CH3)2 + Br2 → HO2CCHBrCH(CH3)2 + HBr
HO2CCHBrCH(CH3)2 + 2 NH3 → HO2CCH(NH2)CH(CH3)2 + NH4Br
.
[Purification Methods]

Crystallise L-valine from water by addition of EtOH. It sublimes at 178-188o/0.03mm with 99.3% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Perrin J Chm Soc 3125 1958, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2368-23771961, Beilstein 4 IV 2659.]
[Nomenclature]

According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons.
Questions And AnswerBack Directory
[Amino acids]

L-Valine is a kind of branched-chain amino acids (BCAA). Animal cannot synthesize it by itself. It must be obtained from the diet to meet their nutritional needs. Therefore L-valine belongs to the essential amino acids.
Amino acids are the basic structural unit of protein synthesis, and the predecessor of other amines that metabolism needs. They are indispensable materials in our life. At present, it is known that there are 20 to 30 amino acids. Some of them can be synthesized in the human body, which are known as non-essential amino acids. And some, called essential amino acids, cannot be synthesized in the human body that should be supplemented from the outside. Mammal cells need twelve essential amino acids: L-arginine, L-cystine, L-histidine, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L-valine. These amino acids are all laevoisomer, and some non-essential amino acids of dextroisomer may have inhibitory effect on cultured cells.
L-amino acids can easier to be absorbed than D-amino acids. And the absorption of D, L-methionine has no difference. There is competition between the body transport of amino acids. The transporting of an amino acid can be suppressed by the presence of another amino acid. For example, L-valine and L-methionine can inhibit the absorption of L-leucine. Excessive lysine in dietary can inhibit the absorption of arginine. High concentration (100mM) of L-valine has no effect on the absorption of L-methionine. Because it can be transported through another route.
[Content Analysis]

About 200mg sample is accurately weighed, dissolved in 3ml formic acid and 50ml glacial acetic acid. Add 2 drops of crystal violet test solution (TS-74), then use 0.1mol/L perchloric acid to titrate the solution to green or blue disappear entirely. Each Ml0.1mol/L perchloric acid is equivalent to 11.72mg L-valine (C5H11NO2).
[Chemical property]

White crystal or crystalline powder, odorless, bitter taste. Soluble in water, solubility in water of 8.85% at 25℃. Almost insoluble in ethanol, ether, acetone. melting point(decomposition point) 315℃, isoelectric point 5.96, [α]25D+28.3 (C = 1-2g/ml, in 5mol/L HCl).
[Uses]

  • Amino acids drugs, nutritional supplements. It can be used as the main component of aminophenol transfusion and synthesize aminophenol. L-Valine is one of the three branched-chain amino acids. It is essential amino acid. It can be used to treat liver failure and central nervous system dysfunction.
  • L-Valine is essential amino acid. The requirement for men is 10mg/(kg·d). Physiological effects of the L-form is 2 times of the D-type. L-Valine deficiency can cause neurological disorders, blastocolysis, loss of weight, anemia and the like. As nutritional supplements, it can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion. Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine is the essential amino acid. It can be used as one of pharmaceutical composition of amino acid infusion to synthesize drugs. It also can be used as food additives.
  • Nutritional supplements. It can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion.Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine can be used for biochemical research, the preparation of tissue culture media. It also used as amino acids nutritional drugs in medicine.
Spectrum DetailBack Directory
[Spectrum Detail]

L-Valine(72-18-4)MS
L-Valine(72-18-4)1HNMR
L-Valine(72-18-4)13CNMR
L-Valine(72-18-4)IR1
L-Valine(72-18-4)IR2
L-Valine(72-18-4)Raman
L-Valine(72-18-4)ESR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

L-Valine, 99%(72-18-4)
[Alfa Aesar]

L-Valine, 99%(72-18-4)
[Sigma Aldrich]

72-18-4(sigmaaldrich)
[TCI AMERICA]

L-Valine,>98.0%(T)(72-18-4)
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