| Identification | More | [Name]
4-Hydroxy-6-methyl-2-pyrone | [CAS]
675-10-5 | [Synonyms]
3,5-DIHYDROXYSORBIC ACID DELTA-LACTONE
3,5-DIHYDROXYSORBIC ACID OMEGA-LACTONE
3,5-DIHYDROXYSORBIC ACID SIGMA-LACTONE
4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE
4-HYDROXY-6-METHYL-2-PYRONE
6-METHYL-4-HYDROXY-2-PYRANONE
6-METHYL-4-HYDROXY-2-PYRONE
AURORA KA-5368
Triacetate lactone
4-hydroxy-6-methyl-2h-pyran-2-on
6-methyl-4-hydroxypyron-(2)
triaceticacidlactone
4-hydroxy-6-methylpyran-4-one
Hydroxy-6-methyl-2-pyrone,4-
4-Hydroxy-6-Methyl-2-Pyronone
3,5-dihydroxysorbic acid i-lactone
3,5-dihydroxysorbic acid δ-lactone
4-Hydroxy-6-methyl-2-pyrone 98%
188-190℃
4-Hydroxy-6-methylpyran-2-one | [EINECS(EC#)]
211-619-2 | [Molecular Formula]
C6H6O3 | [MDL Number]
MFCD00006641 | [Molecular Weight]
126.11 | [MOL File]
675-10-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
188-190 °C (dec.) (lit.) | [Boiling point ]
174.21°C (rough estimate) | [density ]
1.2048 (rough estimate) | [refractive index ]
1.4189 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
8.6g/l | [form ]
Powder | [pka]
5.14±0.30(Predicted) | [color ]
Off-white to brown | [Water Solubility ]
8.60 g/L (20 ºC) | [BRN ]
113815 | [InChI]
InChI=1S/C6H6O3/c1-4-2-5(7)3-6(8)9-4/h2-3,7H,1H3 | [InChIKey]
NSYSSMYQPLSPOD-UHFFFAOYSA-N | [SMILES]
C1(=O)OC(C)=CC(O)=C1 | [CAS DataBase Reference]
675-10-5(CAS DataBase Reference) | [EPA Substance Registry System]
675-10-5(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
UQ1000000
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29322980 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
4-Hydroxy-6-methylpyran-2-one was used in the synthesis of pyrano[3,2-c]pyridones with antiproliferative and apoptosis inducing activities. It was also used in the design of benzisothiazolone human leukocyte elastase inhibitors. | [Definition]
ChEBI: Triacetate lactone is a member of 2-pyranones. It is a conjugate acid of a triacetate lactone oxoanion. | [Synthesis Reference(s)]
Synthetic Communications, 20, p. 1931, 1990 DOI: 10.1080/00397919008053123 | [Synthesis]
14.4g (0.1mol) isopropylidene malonate, 35ml dichloromethane and 15ml chlorobenzene were placed in the reaction flask, cooled to <5°C under stirring, 10.1g (0.1mol) triethylamine and 10.1g (0.12mol) bis(vinylidene) ketone were added dropwise. After additi |
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