| Identification | More | [Name]
6-Methoxy-1H-indole-3-carbaldehyde | [CAS]
70555-46-3 | [Synonyms]
6-METHOXY-1H-INDOLE-3-CARBALDEHYDE
6-METHOXY-1H-INDOLE-3-CARBOXALDEHYDE
6-METHOXY-3-INDOLECARBOXALDEHYDE
6-METHOXYINDOLE-3-CARBOXALDEHYDE
AKOS JY2083124
TIMTEC-BB SBB005312
6-Methoxy-1H-indole-3-carboxaldehyde 98%
6-METHOXYINDOLE-3-CARBOXALDEHYDE 98% | [Molecular Formula]
C10H9NO2 | [MDL Number]
MFCD03848058 | [Molecular Weight]
175.18 | [MOL File]
70555-46-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
185 °C | [Boiling point ]
375.2±22.0 °C(Predicted) | [density ]
1.273±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
Solid | [pka]
15.73±0.30(Predicted) | [Appearance]
Light brown to brown Solid | [InChI]
InChI=1S/C10H9NO2/c1-13-8-2-3-9-7(6-12)5-11-10(9)4-8/h2-6,11H,1H3 | [InChIKey]
JTEFJNIWWXTBMP-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC(OC)=C2)C(C=O)=C1 | [CAS DataBase Reference]
70555-46-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
6-Methoxy-1H-indole-3-carbaldehyde, is a building block used in various chemical synthesis. | [Synthesis]
GENERAL STEPS: 6-methoxyindole (33 mg) was dissolved in N,N-dimethylformamide (0.04 mL), and this solution was then slowly added dropwise to a pre-cooled mixture of N,N-dimethylformamide (0.07 mL) and phosphorous triclosan (0.07 mL) at 0°C. The reaction was carried out by stirring for 2.5 hours at room temperature. After the dropwise addition was completed, the reaction mixture was stirred for 2.5 hours at room temperature. Upon completion of the reaction, 6-methoxyindole-3-carboxaldehyde was isolated in 98% yield by appropriate post-treatment steps. | [References]
[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 15, p. 4541 - 4549
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 25, p. 6270 - 6282
[3] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 344 - 367
[4] Journal of the Chemical Society, 1958, p. 3493,3494
[5] Synthetic Communications, 1992, vol. 22, # 14, p. 2077 - 2102 |
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