| Identification | More | [Name]
Enoximone | [CAS]
77671-31-9 | [Synonyms]
1,3-DIHYDRO-4-METHYL-5-[4-METHYLTHIOBENZOYL]-2H-IMIDAZOL-2-ONE
ENOXIMONE
2H-Imidazol-2-one, 1,3-dihydro-4-methyl-5-(4-(methylthio)benzoyl)-
Fenoximone
MDL-17043
Pedane
Perfan
RMI-17043 | [Molecular Formula]
C12H12N2O2S | [MDL Number]
MFCD00867130 | [Molecular Weight]
248.3 | [MOL File]
77671-31-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
255-258°C | [density ]
1.33 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO: 28 mg/mL, soluble
| [form ]
solid
| [pka]
10.37±0.70(Predicted) | [color ]
light yellow
| [InChI]
1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16) | [InChIKey]
ZJKNESGOIKRXQY-UHFFFAOYSA-N | [SMILES]
CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2 | [CAS DataBase Reference]
77671-31-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [RIDADR ]
3249 | [WGK Germany ]
3
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Storage Class]
10 - Combustible liquids |
| Hazard Information | Back Directory | [Description]
Enoximone is a phosphodiesterase inhibitor indicated for selective use as a
cardiostimulant in heart transplant patient maintenance. It is currently being investigated
for other indications including acute congestive heart failure. | [Chemical Properties]
Crystallized from isopropyl alcohol-water, melting point 255-258°C (decomposition). | [Originator]
Merrell Dow (USA) | [Uses]
Enoximone is a phosphodiesterase inhibitor used in the treatment of congestive heart failure and is selective to phosphodiesterase 3. Potent PDE-3 inhibitor. | [Definition]
ChEBI: Enoximone is an aromatic ketone. | [Brand name]
Perfan IV | [Biological Activity]
Inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro . | [Biochem/physiol Actions]
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart. | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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