| Identification | More | [Name]
Ozagrel hydrochloride | [CAS]
78712-43-3 | [Synonyms]
(2E)-3-[4-(1H-IMIDAZOL-1-YLMETHYL)PHENYL]-2-PROPENOIC ACID HYDROCHLORIDE
(e)-3-(4-(1h-imidazol-1-ylmethyl)phenyl)-2-propenoic acid hydrochloride
OZAGREL HCL
OZAGREL HYDROCHLORIDE
(e)-3-(4-(1h-imidazol-1-ylmethyl)phenyl)-2-propenoicacidhydrochloridehydra
(e)-ohydrat
2-propenoicacid,3-(4-(1h-imidazol-1-ylmethyl)phenyl)-,monohydrochloride,mon
oky046hydrochloride
oky-046hydrochloride
OZAGREL HYDROCHLORIDE HYDRATE
OzagrelHcl99%
OzagrelHclC13H12N2O2.Hcl
(e)-3-[4-(imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride
OKY-046, (E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrate hydrochloride
Ozagrel hydrate hydrochloride
Domenan
OKY-046 HCl
Vega | [EINECS(EC#)]
928-470-0 | [Molecular Formula]
C13H13ClN2O2 | [MDL Number]
MFCD06795644 | [Molecular Weight]
264.71 | [MOL File]
78712-43-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
214-217° | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
H2O: soluble
| [form ]
solid
| [color ]
white to off-white
| [Water Solubility ]
H2O: soluble | [Merck ]
14,6980 | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month. | [CAS DataBase Reference]
78712-43-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM).1?Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2?isomerase (IC50 > 1 mM).1?Inhibits platelet aggregation2?in vitro?and arachidonate-induced arterial contraction?in vivo. Ozagrel HCl protects against arachidonate-induced sudden death in the rabbit3, and alleviates liver injury induced by acetaminophen overdose in mice4. | [Uses]
Antithrombotic;Thromboxane synthase inhibitor | [Definition]
ChEBI: Ozagrel hydrochloride is an organic molecular entity. | [IC 50]
TXA2/TP | [References]
1) Hiraku?et al. (1986),?Pharmacological studies on the TXA2?synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046); Jpn. J. Pharmacol.,?41?393
2) Naito?et al. (1983), Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets; Eur. J. Pharmacol.,?91?41
3) Edmonds and Leffer (1984),?Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death; Life Sci.,?35?1763
4) Tomishima?et al. (2013),?Ozagrel hydrochloride, a selective thromboxane A2?synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice; BMC Gastroenterol.,?30?13 |
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